EBQ:Lactate clearance vs central venous oxygen saturation: Difference between revisions
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==Inclusion Criteria== | ==Inclusion Criteria== | ||
*>17 years old AND | |||
*confirmed or presumed infection meeting criteria for severe sepsis or septic shock: | |||
**2 or more SIRS criteria AND | |||
**SBP <90 after 20 mL/kg bolus or blood lactate at least 36 mg/dL | |||
==Exclusion Criteria== | ==Exclusion Criteria== | ||
Revision as of 06:54, 4 November 2014
incomplete Journal Club Article
Jones AE.. "Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial". JAMA. 2010. 303(8):739-746.
PubMed Full text PDF
PubMed Full text PDF
Clinical Question
Is lactate clearance as good as SVO2 as a measure of oxygen delivery to tissues in patients presenting with severe sepsis and septic shock?
Conclusion
For patients with septic shock who were treated by normalizing CVP and MAP; attempt to normalize lactate clearance as opposed to normalize SVO2 showed no significant difference in in-hospital mortality.
Major Points
Inclusion Criteria
- >17 years old AND
- confirmed or presumed infection meeting criteria for severe sepsis or septic shock:
- 2 or more SIRS criteria AND
- SBP <90 after 20 mL/kg bolus or blood lactate at least 36 mg/dL