Malignant bone tumors: Difference between revisions
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| align="center" style="background:#f0f0f0;"|'''Clinical Importance''' | | align="center" style="background:#f0f0f0;"|'''Clinical Importance''' | ||
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| Adamantinoma||Bone pain over anterior tibia in adolescent or young adult||Soap Bubble osteolytic appearance on plain radiograph|| | | Adamantinoma||Bone pain over anterior tibia in adolescent or young adult||Soap Bubble osteolytic appearance on plain radiograph||Metastasis to lungs; may need amputation | ||
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| Chordoma||Constant pain if in sacrum; neurological deficits if at base of skull, most commonly in cranial nerves to the eye ||Plain radiograph will show a destructive bone lesion often with an associated soft tissue mass||Slow growing but locally aggressive; metastasis is uncommon, local recurrence is much more likely | |||
| Chordoma|| | |||
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| Fibrosarcoma and Undifferentiated pleomorphic sarcoma||Similar to osteosarcoma except malignant fibroblasts but less common||Most common in distal femur and proximal tibia||Similar outcome to osteosarcoma | | Fibrosarcoma and Undifferentiated pleomorphic sarcoma||Similar to osteosarcoma except malignant fibroblasts but less common||Most common in distal femur and proximal tibia||Similar outcome to osteosarcoma | ||
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| Primary bone lymphoma||Adult > 40 years of age with bone pain or pathologic fracture|| | | Primary bone lymphoma||Adult > 40 years of age with bone pain or pathologic fracture||Bone destruction; soft tissue mass||5 year survival is greater than 50% with radiation and chemotherapy | ||
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Revision as of 23:07, 21 November 2019
Background
Clinical Features
Differential Diagnosis[1]
| Name | Presentation | Radiograph Findings | Clinical Importance |
| Adamantinoma | Bone pain over anterior tibia in adolescent or young adult | Soap Bubble osteolytic appearance on plain radiograph | Metastasis to lungs; may need amputation |
| Chordoma | Constant pain if in sacrum; neurological deficits if at base of skull, most commonly in cranial nerves to the eye | Plain radiograph will show a destructive bone lesion often with an associated soft tissue mass | Slow growing but locally aggressive; metastasis is uncommon, local recurrence is much more likely |
| Fibrosarcoma and Undifferentiated pleomorphic sarcoma | Similar to osteosarcoma except malignant fibroblasts but less common | Most common in distal femur and proximal tibia | Similar outcome to osteosarcoma |
| Primary bone lymphoma | Adult > 40 years of age with bone pain or pathologic fracture | Bone destruction; soft tissue mass | 5 year survival is greater than 50% with radiation and chemotherapy |
Evaluation
Management
Disposition
References
- ↑ Niederhuber, John E., et al. “Sarcomas.” Abeloff's Clinical Oncology E-Book. Elsevier Health Sciences, 2019, pp. 1604 – 1654.e8.