Ewing sarcoma: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Constant pain for months over site of malignancy | |||
**Worse with exercise and at night | |||
*Site will be edematous and tender to palpation | |||
**Mass can sometimes be appreciated | |||
*Most often found in pelvis, axial skeleton, or diaphysis of femur with a small minority arising in soft tissues | |||
*Pelvic tumors are more regularly associated with metastatic disease | |||
*Fever, weight loss, fatigue, night sweats occur in less than 20 percent of patients | |||
*Pathological fractures can occur | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 22:35, 21 November 2019
Background
- Highly aggressive malignant bone or soft tissue tumor arising from cells of the neuroectoderm
- One-fourth of patients will have metastasis at the time of presentation
- It is assumed that almost all patients have subclinical metastasis
- Presence and location of metastasis is the major prognostic factor for survival
- Metastasis is most frequently seen in bone (spine most common) and lungs
- Around 70 to 80 percent survival in those with non-metastatic disease
- More common in males
Clinical Features
- Constant pain for months over site of malignancy
- Worse with exercise and at night
- Site will be edematous and tender to palpation
- Mass can sometimes be appreciated
- Most often found in pelvis, axial skeleton, or diaphysis of femur with a small minority arising in soft tissues
- Pelvic tumors are more regularly associated with metastatic disease
- Fever, weight loss, fatigue, night sweats occur in less than 20 percent of patients
- Pathological fractures can occur