Osteosarcoma: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
*Overproduction of osteoid and immature bone by malignant osteoblasts | *Overproduction of osteoid and immature bone by malignant osteoblasts | ||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 21:34, 21 November 2019
Background
- Most common primary pediatric bone tumor
- 3% of all childhood cancers
- Around two-thirds of those diagnosed with non-metastatic disease under the age of 40 will be long-term survivors or cured of the disease with appropriate treatment
- Survival is less than 20 percent with metastatic disease
- Bimodal as it peaks in early adolescence and over the age of 65
Pathophysiology
- Overproduction of osteoid and immature bone by malignant osteoblasts