Rimantadine

Administration

• Type: Antiviral
• Dosage Forms:
• Routes of Administration: oral
• Common Trade Names:

Adult Dosing

• Influenza A: 100 mg PO BID

Pediatric Dosing

• <10 years old: 5 mg/kg PO daily, max 150 mg/day
• 10 years or older: 100 mg PO BID

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing, CrCl <30: 100 mg PO daily
• Severe liver disease: 100 mg PO daily

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Heart block, syncope heart failure
• Cerebrovascular and spinal vascular disorders
• Seizure
• Hallucinations
• Bronchospasm

Common

• Nausea/vomiting, abdominal pain, anorexia, xerostomia
• Asthenia, dizziness, fatigue
• Nervousness, insomnia
• Headache

Pharmacology

• Half-life: ~25h
• Metabolism: Hepatic
• Excretion: Mostly renal

Mechanism of Action

• Not well understood, interferes with viral M2 protein

See Also

• Influenza