Miconazole

Administration

• Type: Antifungal
• Dosage Forms: 2% Cream
• Routes of Administration: Topical
• Common Trade Names: Monistat-Derm, Desenex, Lotrimin, Micatin, Zeasorb

Adult Dosing

Candidiasis, cutaneous

• Apply 2% Cream BID to affected area x2 weeks

Tinea corporis

• Apply 2% Cream BID to affected area x4 weeks

Tinea cruris

• Apply 2% Cream BID to affected area x2 weeks

Tinea pedis

• Apply 2% Cream BID to affected area x4 weeks

Pediatric Dosing

Candidiasis, cutaneous

• Apply 2% Cream BID to affected area x2 weeks

Tinea corporis

• Apply 2% Cream BID to affected area x4 weeks

Tinea cruris

• Apply 2% Cream BID to affected area x2 weeks

Tinea pedis

• Apply 2% Cream BID to affected area x4 weeks

Special Populations

Pregnancy Rating

• Risk of fetal harm no expected
• May use during pregnancy

Lactation risk

• May use while breastfeeding

Renal Dosing

• Adult: Not defined
• Pediatric: Not defined

Hepatic Dosing

• Adult: Not defined
• Pediatric: Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• May occur, but none reported

Common

• Irritation, burning, stining
• Pruritus, erythema, maceration
• Contact dermatitis

Pharmacology

• Half-life: Unknown
• Metabolism: None, minimal systemic absorption
• Excretion: None

Mechanism of Action

• Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis