Amlodipine: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Antihypertensive]] (dihydropyridine-[[CCBs|CCB]]) | ||
*Dosage Forms: tablet | *Dosage Forms: tablet | ||
*Dosage Strengths: 2.5mg, 5mg, 10mg | *Dosage Strengths: 2.5mg, 5mg, 10mg | ||
| Line 32: | Line 32: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Angina, MI | *Angina, MI | ||
*Hypotension | |||
*Hepatitis | |||
*Erythema multiforme | |||
===Common=== | ===Common=== | ||
*Peripheral edema | *Peripheral edema | ||
*Fatigue | |||
*Palpitations | |||
*Dizziness | |||
*Nausea | |||
*Flushing | |||
*Eczematous eruptions | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 02:32, 23 August 2019
General
- Type: Antihypertensive (dihydropyridine-CCB)
- Dosage Forms: tablet
- Dosage Strengths: 2.5mg, 5mg, 10mg
- Routes of Administration: PO
- Common Trade Names: Norvasc
Adult Dosing
- hypertension
- 5-10mg PO qDaily
- Start: 5mg PO qDaily for intial antihypertesnive, do 2.5 if elderly or 2nd line drug
Pediatric Dosing
- hypertension
- 2.5-5mg PO qDaily
Special Populations
- Pregnancy Rating: C
- Lactation: Safety Unknown
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: Start at 2.5mg qDaily
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Severe CAD, AS, CHF
- Re-dose/Caution: Elderly/Hepatic Impairment
Adverse Reactions
Serious
- Angina, MI
- Hypotension
- Hepatitis
- Erythema multiforme
Common
- Peripheral edema
- Fatigue
- Palpitations
- Dizziness
- Nausea
- Flushing
- Eczematous eruptions
Pharmacology
- Half-life: 30-50h
- Metabolism: liver extensively; CYP450: 3A4
- Excretion: urine 59-62% (5-10% unchanged), bile/feces 20-25%
- Mechanism of Action: CCB-dihydropyridine