Streptomycin: Difference between revisions
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*1-2 g/day IM divided q6-12h | *1-2 g/day IM divided q6-12h | ||
** Max: 2 g/day; Info: adjust dose based on serum levels | ** Max: 2 g/day; Info: adjust dose based on serum levels | ||
**Renal dosing | |||
***Creatinine Clearance 50-80: give q24h | |||
***Creatinine Clearance 10-50: give q24-72h | |||
***Creatinine Clearance <10: give q72-96h | |||
===Active | ===Active tuberculosis=== | ||
*15 mg/kg IM q24h 5-7x/wk | *15 mg/kg IM q24h 5-7x/wk | ||
**Alternative: 25-30 mg/kg IM 2-3x/wk | **Alternative: 25-30 mg/kg IM 2-3x/wk | ||
===Plague=== | |||
*1g IM q12h x10 days | |||
**Maximum dose: 2 g/day (adjust dose based on serum levels) | |||
===Tularemia=== | |||
*1g IM q12h x10 days | |||
**Maximum dose: 2 g/day (adjust dose based on serum levels) | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Infections, Bacterial=== | |||
*20-40 mg/kg IM q24h | |||
**Alternative: 20-40 mg/kg IM 2x/wk | |||
**Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk | |||
**Renal dosing | |||
***Creatinine Clearance 50-80: 7.5 mg/kg give q24h | |||
***Creatinine Clearance 10-50: 7.5 mg/kg give q24-72h | |||
***Creatinine Clearance <10: 7.5 mg/kg give q72-96h | |||
===Active tuberculosis=== | |||
* 20-40 mg/kg IM q24h | |||
**Alternative: 20-40 mg/kg IM 2x/wk | |||
**Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk | |||
===Plague=== | |||
* 15 mg/kg IM q12h x10 days | |||
**Maximum dose: 2 g/day (adjust dose based on serum levels) | |||
**Maximum dose: 2 g/day (adjust dose based on serum levels) | |||
===Tularemia=== | |||
* 15 mg/kg IM q12h x10 days | |||
==Contraindications / cautions== | |||
*caution if hypersensitivity to sulfites | |||
*caution if impaired vestibular function | |||
*caution if impaired auditory function | |||
*caution if concurrent ototoxic agents | |||
*caution if concurrent neurotoxic agents | |||
*caution if neuromuscular disease | |||
*caution if renal impairment | |||
*caution if dehydration | |||
*caution if concurrent nephrotoxic agent use | |||
*caution if electrolyte abnormalities | |||
*caution if prolonged use | |||
*caution in neonates or infants | |||
*caution in elderly patients | |||
==See Also== | ==See Also== | ||
Revision as of 02:30, 14 July 2014
General
- Type: Aminoglycosides
- Dosage Forms:
- IM
Adult Dosing
Infections, Bacterial
- 1-2 g/day IM divided q6-12h
- Max: 2 g/day; Info: adjust dose based on serum levels
- Renal dosing
- Creatinine Clearance 50-80: give q24h
- Creatinine Clearance 10-50: give q24-72h
- Creatinine Clearance <10: give q72-96h
Active tuberculosis
- 15 mg/kg IM q24h 5-7x/wk
- Alternative: 25-30 mg/kg IM 2-3x/wk
Plague
- 1g IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Tularemia
- 1g IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Pediatric Dosing
Infections, Bacterial
- 20-40 mg/kg IM q24h
- Alternative: 20-40 mg/kg IM 2x/wk
- Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
- Renal dosing
- Creatinine Clearance 50-80: 7.5 mg/kg give q24h
- Creatinine Clearance 10-50: 7.5 mg/kg give q24-72h
- Creatinine Clearance <10: 7.5 mg/kg give q72-96h
Active tuberculosis
- 20-40 mg/kg IM q24h
- Alternative: 20-40 mg/kg IM 2x/wk
- Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
Plague
- 15 mg/kg IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Tularemia
- 15 mg/kg IM q12h x10 days
Contraindications / cautions
- caution if hypersensitivity to sulfites
- caution if impaired vestibular function
- caution if impaired auditory function
- caution if concurrent ototoxic agents
- caution if concurrent neurotoxic agents
- caution if neuromuscular disease
- caution if renal impairment
- caution if dehydration
- caution if concurrent nephrotoxic agent use
- caution if electrolyte abnormalities
- caution if prolonged use
- caution in neonates or infants
- caution in elderly patients