Piperacillin/Tazobactam: Difference between revisions
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==Pediatric Dosing<ref>Red Book, 2012</ref>== | ==Pediatric Dosing<ref>Red Book, 2012</ref>== | ||
'''Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)''' | '''A Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)''' | ||
===General=== | ===General=== | ||
*'''<2 months''' | *'''<2 months''' | ||
Revision as of 18:03, 15 April 2014
General
- Type: Anti-Pseudomonal Penicillin
- Dosage Forms:
- Common Trade Names: Zosyn
Adult Dosing
General
- 3.375 g IV q6 hours
- Alt: 4.5 g q6-8 hours
- Max: 18 g/day
Diverticulitis
- 3.375 g IV q6 hours x 7-10 days
Pneumonia
- CAP
- 3.375 g IV q6 hours x 7-10 days
- Only for P. aeruginosa caused or from aspiration[1]
- Nosocomial
- 4.5 g IV q6 hours x 7-14 days
- + aminoglycoside or antipseudomonal fluoroquinolone
Pediatric Dosing[2]
A Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)
General
- <2 months
- 100 mg piperacillin/kg/dose IV q6 hours
- 2-9 months
- 80 mg piperacillin/kg/dose IV q8 hours
- >9 months
- 100 mg piperacillin/kg/dose q8 hours
- Max: 16 g/day
Appendicitis and/or Peritonitis
- 2-9 months
- 80 mg piperacillin/kg/dose q8 hours
- >9 months
- ≤40 kg: 100 mg piperacillin/kg/dose q8 hours
- >40 kg: 3.375g (3000 mg piperacillin) q6 hours
- Max: 16 g/day
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: