Clindamycin

General

• Type: Other antibiotics
• Dosage Forms: IM, IV, PO (150mg; 300mg)
• Common Trade Names: Cleocin

Adult Dosing

General

• PO:
  • 150-450mg PO q6h
  • First Dose: 150-450mg PO x 1
  • Max: 450 mg/dose PO (increased risk of C. diff at higher doses)
• IM:
  • 600-2700 mg/day IM divided q6-12h
  • First Dose: 600 mg IM x 1
  • Max: 600 mg/dose IM
• IV
  • 600-2700 mg/day IV divided q6-12h
  • First Dose: 600-900 mg IV x 1
  • 4800 mg/day IV

Strep. Pharyngitis

• 300mg PO q8 x 10 days

Bacterial Vaginosis

• 300mg PO q12h x 7 days

PID

• Mild-mod
  • 450mg PO q6h x 14 days
  • Use with ceftriaxone or cefoxitin/probenecid if no proceeding IV treatment
• Severe
  • 900mg IV q8
  • Use with gentamicin and switch to PO after 24h of clinical improvement

Babesiosis

• 600 mg PO q8h x 7-10 days
• Alt: 300-600mg IV q6h x 7-10 days
  • First Dose: 300-600mg IV x 1
• Give with quinine; use IV for severe infections

Special Populations

• Pregnancy: B
• Lactation: Possibly unsafe
• Renal Dosing (Adult & Pediatric)
  • No adjustment
  • No supplement for hemodialysis or peritoneal dialysis
  • Pediatric
• Hepatic Dosing (Adult & Pediatric)
  • No adjustment

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Antibiotics (Main)