Trimethoprim-Sulfamethoxazole DS: Difference between revisions
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*Dosage Forms: 160/800 | *Dosage Forms: 160/800 | ||
*Common Trade Names: Bactrim DS | *Common Trade Names: Bactrim DS | ||
*Abbreviations: TMP-SMX, TMP-SMZ | |||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 05:17, 27 February 2014
General
- Type: Sulfonamide
- Dosage Forms: 160/800
- Common Trade Names: Bactrim DS
- Abbreviations: TMP-SMX, TMP-SMZ
Adult Dosing
General
1 tab (160mg TMP) PO Q12h
PCP Prophylaxis
80-160mg TMP PO daily
PCP Treatment
15-20 mg/kg/day TMP PO divided q6-8h x 21 days
Pediatric Dosing
General (>2mo)
- Mild-mod infection
- 4-5 mg/kg TMP PO q12hr
- Severe infection
- 15-20 mg/kg/dy TMP PO divided q6-8h
Contraindications
- Allergy to class/drug
- <2 months of age (except as PCP prophylaxis)
- sig hepatic impairment
- megaloblastic anemia or folate deficiency
- G6PD deficiency
Adverse Reactions
Pharmacology
- Half-life: 6-12h (20-50h ESRD)
- Metabolism:
- Excretion:
- Mechanism of Action: Bactericidal
Pregnancy/Lactation
- Pregnancy: D
- Lactation: ?