Glucagon: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: IV: 8-18 minutes IM: 45 minutes | ||
*Metabolism: | *Metabolism: Liver, kidney | ||
*Excretion: | *Excretion: unknown | ||
*Mechanism of Action: | *Mechanism of Action: Stimulates hepatic glycogenolysis. GI smooth muscle relaxent | ||
==See Also== | ==See Also== | ||
Revision as of 15:15, 13 October 2017
General
- Type:
- Dosage Forms:
- Common Trade Names: GlucaGen
Adult Dosing
Hypoglycemia
- 1mg SC/IM/IV x 1
- May repeat q20 min PRN
Beta-blocker toxicity[1] [2]
- 5mg IV bolus over one minute
- Rebolus if no response after 10min
- If effective, start infusion at 2-5mg/hr
Pediatric Dosing
Hypoglycemia
- 0.03mg/kg IM/SQ/IV x 1 (max = 1mg)
- Alternative
- <20kg: 0.5mg SC/IM/IV x 1
- >20kg: 1mg SC/IM/IV x 1
- May repeat q20 min
Beta-blocker toxicity [1] [2]
- 50mcg/kg
- Rebolus if no response after 10min
- If effective, start infusion at 70mcg/kg/hr
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- insulinoma
- pheochromocytoma
Adverse Reactions
Serious
- hypersensitivity reaction
- anaphylaxis
- hypotension
Common
- Nausea and vomiting
- hyperglycemia
Pharmacology
- Half-life: IV: 8-18 minutes IM: 45 minutes
- Metabolism: Liver, kidney
- Excretion: unknown
- Mechanism of Action: Stimulates hepatic glycogenolysis. GI smooth muscle relaxent
See Also
References
- ↑ 1.0 1.1 Kerns W. Management of beta-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am. 2007;25(2):309-331. (Review)
- ↑ 2.0 2.1 Bailey B (2003). Glucagon in beta-blocker and calcium channel blocker overdoses: a systematic review. Journal of toxicology. Clinical toxicology, 41 (5), 595-602 PMID: 14514004