Aluminum toxicity: Difference between revisions
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==Aluminum oxide== | ==Aluminum oxide== | ||
*Physical irritant, nuisance particulate | *Physical irritant, nuisance particulate | ||
==Systemic aluminum toxicity=== | |||
*Usually in renal patients on long-term dialysis with aluminum-containing dialysate | |||
*Rarely acute | |||
*Muscle weakness (especially proximal) | |||
*Premature osteoporosis, bone pain, multiple fractures | |||
*Seziures | |||
*Acute or subacute [[altered mental status]] | |||
==Evaluation== | ==Evaluation== | ||
*Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity | |||
**Symptomatic patients with levels 20-50 may also need treatment | |||
==Management== | ==Management== | ||
*Stop exposure | |||
*Chelation with [[deferoxamine]] for severe or symptomatic systemic toxicity | |||
==Disposition== | ==Disposition== | ||
Revision as of 15:16, 22 August 2017
Aluminum Metal
- Dusts cause respiratory tract and eye irritation
- Acute exposures can cause bronchoconstriction and asthma-like response
- Chronic exposure can lead to pulmonary fibrosis
- Increased incidence of cancer
Aluminum phosphide
- Used as a fumigant
- Contact with moisture produces phosphine gas
- Respiratory tract irritant
Aluminum oxide
- Physical irritant, nuisance particulate
Systemic aluminum toxicity=
- Usually in renal patients on long-term dialysis with aluminum-containing dialysate
- Rarely acute
- Muscle weakness (especially proximal)
- Premature osteoporosis, bone pain, multiple fractures
- Seziures
- Acute or subacute altered mental status
Evaluation
- Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity
- Symptomatic patients with levels 20-50 may also need treatment
Management
- Stop exposure
- Chelation with deferoxamine for severe or symptomatic systemic toxicity