Sodium thiosulfate: Difference between revisions
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== | ==Administration== | ||
* | *Type: | ||
* | *Dosage Forms: | ||
*Routes of Administration: | |||
*Common Trade Names: | |||
==Adult Dosing== | |||
===[[Cyanide toxicity]]=== | |||
*Adult: 12.5 g IV | |||
===Prophylaxis during nitroprusside infusion=== | |||
*Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside | |||
==Pediatric Dosing== | |||
===[[Cyanide toxicity]]=== | |||
*Pediatric: 400 mg/kg IV | |||
===Prophylaxis during nitroprusside infusion=== | |||
*Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside | |||
==Special Populations== | |||
*[[Drug pregnancy categories|Pregnancy Rating]]: C | |||
*Lactation risk: | |||
===Renal Dosing=== | |||
*Adult: | |||
*Pediatric: | |||
===Hepatic Dosing=== | |||
*Adult: | |||
*Pediatric: | |||
==Indications== | ==Indications== | ||
| Line 9: | Line 36: | ||
==Contraindications== | ==Contraindications== | ||
* | *Allergy to class/drug | ||
==Adverse Reactions== | |||
===Serious=== | |||
== | ===Common=== | ||
*Burning sensation and muscle cramping from infusion | *Burning sensation and muscle cramping from infusion | ||
== | ==Pharmacology== | ||
* | *Half-life: | ||
* | *Metabolism: | ||
* | *Excretion: | ||
* | |||
* | ==Mechanism of Action== | ||
==Comments== | |||
*Sulfur donor that promotes conversion of cyanide to thiocyanate | |||
*Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic | |||
==See Also== | ==See Also== | ||
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==References== | ==References== | ||
<references/> | |||
*Olson, K. Poisoning and Drug Overdose, 1999. | *Olson, K. Poisoning and Drug Overdose, 1999. | ||
[[Category:Pharmacology]] | |||
[[Category:Toxicology]] | [[Category:Toxicology]] | ||
Revision as of 05:21, 17 May 2017
Administration
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Cyanide toxicity
- Adult: 12.5 g IV
Prophylaxis during nitroprusside infusion
- Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside
Pediatric Dosing
Cyanide toxicity
- Pediatric: 400 mg/kg IV
Prophylaxis during nitroprusside infusion
- Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside
Special Populations
- Pregnancy Rating: C
- Lactation risk:
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Indications
- Acute cyanide toxicity
- Smoke inhalation with potential for cyanide exposure
- Prophylaxis during nitroprusside infusions
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Burning sensation and muscle cramping from infusion
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
Comments
- Sulfur donor that promotes conversion of cyanide to thiocyanate
- Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic
See Also
References
- Olson, K. Poisoning and Drug Overdose, 1999.