Bath salts toxicity: Difference between revisions
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*IV hydration | *IV hydration | ||
*Monitor urine output | *Monitor urine output | ||
==Complications== | |||
*[[Rhabdomyolysis]] | |||
*[[Cardiomyopathy]] | |||
*[[Valvular heart disease]] | |||
*Cardiac arrhythmias | |||
*[[Pulmonary hypertension]] | |||
*[[Aortic dissection]] | |||
*Acute tubular necrosis | |||
==Disposition== | ==Disposition== | ||
Revision as of 23:10, 6 May 2017
Background
- Found in herbal products sold under guise of "not for human consumption"
- May be found under brand name Aura, Ivory wave, Vanilla sky
- Active ingredients vary; often contain methylenedioxyprovalerone (MDPV) or mephedrone
- Similar effects to Ecstasy (MDMA), cocaine, methamphetamines
Clinical features
Sympathomimetic toxicity + Psychomotor agitation + Hallucinations
- Sympathomimetic toxidrome
- Tachycardia
- Hypertension
- Agitation
- Paranoia
- Hyperthermia
- Hallucinogenic
Evaluation
- Diagnosis based on history and physical exam
Work-Up
- Fingerstick glucose
- Complete metabolic panel
- LFTs
- Coags
- Total CK
- Utox not helpful, usually negative
Differential Diagnosis
Sympathomimetics
- Cocaine
- Amphetamines
- Synthetic cathinones (khat)
- Ketamine
- Ecstasy (MDMA)
- Synthetic cannabinoids
- Bath salts
Management
- Benzodiazepines for agitation
- Do not use butyrophenones (Haldol) or second gen antipsychotic (Geodon) first line
- Interfere with heat dissipation, lower seizure threshold, may prolong QTc
- Rapid cooling for hyperthermia
- Paralyze if hyperthermia uncontrolled (avoid Succinylcholine due to hyperkalemia)
- IV hydration
- Monitor urine output
Complications
- Rhabdomyolysis
- Cardiomyopathy
- Valvular heart disease
- Cardiac arrhythmias
- Pulmonary hypertension
- Aortic dissection
- Acute tubular necrosis
Disposition
- Discharge if AMS and sympathomimetic symptoms resolve with out end-organ damage
- Admit for lab abnormalities or persistent AMS