Template:Thrombocytopenia: Difference between revisions
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====Drug Induced==== | ====Drug Induced==== | ||
*sulfa antibiotics, ETOH, ASA, thiazides/furosemide | *sulfa antibiotics, ETOH, ASA, thiazides/furosemide | ||
====Comparision by Etiology==== | |||
{| class="wikitable" style="text-align:center" | |||
! | |||
! [[Idiopathic thrombocytopenic purpura|ITP]] | |||
! [[Thrombotic Thrombocytopenic Purpura (TTP)|TTP]] | |||
! [[Hemolytic Uremic Syndrome (HUS)|HUS]] | |||
! [[Heparin-Induced Thrombocytopenia (HIT)|HIT]] | |||
! [[Disseminated intravascular coagulation|DIC]] | |||
|- | |||
! ↓ PLT | |||
|Yes||Yes||Yes||Yes||Yes | |||
|- | |||
! ↑PT/INR | |||
||No||No||No||+/-||Yes | |||
|- | |||
!MAHA | |||
||No||Yes||Yes||No||No | |||
|- | |||
!↓ Fibrinogen | |||
||No||No||No||No||Yes | |||
|- | |||
!Ok to give PLT | |||
||Yes||No||No||No||Yes | |||
|- | |||
|} | |||
Revision as of 16:35, 1 March 2017
Thrombocytopenia
Decreased production
- Marrow infiltration (tumor or infection)
- Viral infections (rubella, HIV)
- Marrow Suppression (commonly chemotherapy or radiation)
- Congentital thrombocytopenia
- Fanconi anemia
- Alport syndrome
- Bernand Soulier
- Vitamin B12 and/or folate deficiency
Increased platelet destruction or use
- Idiopathic thrombocytopenic purpura
- Thrombotic Thrombocytopenic Purpura (TTP)
- Hemolytic Uremic Syndrome (HUS)
- Disseminated Intravascular Coagulation (DIC)
- Viral infections (HIV, mumps, varicella, EBV)
- Drugs (heparin, protamine)
- Postransfusion or Posttransplantation
- Autoimmune destruction (SLE or Sarcoidosis)
- Mechanical destruction
- Artificial valves
- ECMO
- HELLP syndrome
- Excessive hemorrhage
- Hemodialysis, extracorporeal circulation
- Splenic Sequestration
- Occurs in Sickle cell disease and Cirrhosis
Drug Induced
- sulfa antibiotics, ETOH, ASA, thiazides/furosemide
Comparision by Etiology
| ITP | TTP | HUS | HIT | DIC | |
|---|---|---|---|---|---|
| ↓ PLT | Yes | Yes | Yes | Yes | Yes |
| ↑PT/INR | No | No | No | +/- | Yes |
| MAHA | No | Yes | Yes | No | No |
| ↓ Fibrinogen | No | No | No | No | Yes |
| Ok to give PLT | Yes | No | No | No | Yes |