Iodoquinol: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones | ||
*Concerns with optic neuritis | *Concerns with optic neuritis | ||
*Concerns with peripheral neuropathy | *Concerns with peripheral neuropathy | ||
*Hepatic impairment | |||
*Renal impairment | |||
*Chronic diarrhea, especially in children | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | |||
* | *Peripheral neuropathy, Long-term (high-dose) | ||
* | *Optic atrophy, Long-term (high-dose) | ||
* | *Optic neuritis, Long-term (high-dose) | ||
===Common=== | |||
* | *Nausea/vomiting, diarrhea, cramps | ||
*Fever/chills | |||
* | *Pruritus, urticaria | ||
* | *Headache, dizziness | ||
* | |||
==Pharmacology== | ==Pharmacology== | ||
| Line 44: | Line 46: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Contact amebicide that works in the lumen of the intestine (unknown mechanism) | |||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
*[[Parasitic diseases]] | |||
==References== | ==References== | ||
<UpToDate> | <UpToDate> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Revision as of 17:33, 24 December 2016
Administration
- Type: Amebicide
- Routes of Administration: Oral
- Common Trade Names: Aloquin; Yodoxin
Adult Dosing
- 650mg 3 times daily after meals for 20 days
- Not to exceed 1.95 g daily
Pediatric Dosing
- Children: 30-40mg/kg daily (maximum: 650mg per dose) in 3 divided doses for 20 days
- Not to exceed 1.95 g daily
Special Populations
- Limited data on use during pregnancy
Renal Dosing
- No adjustments noted by manufacturer
Hepatic Dosing
- No adjustments noted by manufacturer
Contraindications
- Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones
- Concerns with optic neuritis
- Concerns with peripheral neuropathy
- Hepatic impairment
- Renal impairment
- Chronic diarrhea, especially in children
Adverse Reactions
Serious
- Peripheral neuropathy, Long-term (high-dose)
- Optic atrophy, Long-term (high-dose)
- Optic neuritis, Long-term (high-dose)
Common
- Nausea/vomiting, diarrhea, cramps
- Fever/chills
- Pruritus, urticaria
- Headache, dizziness
Pharmacology
- Half-life:
- Metabolism: Liver
- Excretion: Feces, urine
Mechanism of Action
- Contact amebicide that works in the lumen of the intestine (unknown mechanism)
Comments
See Also
References
<UpToDate>