Ricin: Difference between revisions
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Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206: | Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206: | ||
[[Category:Tox]] | |||
Revision as of 17:07, 26 July 2013
Background
- found in castor beans from the plant _Ricinus communis
- a residual product of the production of castor oil (if properly prepared, does not contain the toxin)
Clinical Presentation
- depends on whether the exposure is parenteral, inhaled, or ingested.
- The 1st symptoms of toxicity generally occur 6-12 hours after exposure but can occur as early as 3 hours.
- multiorgan failure occurred with a prominently elevated white blood cell count.
- acute lung injury
- Pulmonary edema may develop one to 3 days after exposure,
- sublethal and accidental exposures were said
to have occurred and were manifest 4-8 hours after exposure
- fever, cough, shortness of breath, and nausea.
- Chest x-ray would be expected to show bilateral infiltrates.
- symptoms and time to death were also dose
related and associated with alveolar flooding, fibropurulent pneumonia, and necrotizing tracheitis. Death occurred 36 to 48 hours after challenge following a 8-24 hour preclinical period.
Source
Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206: