Phenazopyridine: Difference between revisions
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Revision as of 19:13, 28 September 2016
Administration
- Type: Genitourinary
- Dosage Forms: 100, 200 mg
- Routes of Administration: PO
- Common Trade Names: Pyridium, Azo Urinary Pain Relief, Uricalm Max, Uristat
Adult Dosing
Dysuria
- 100-200mg PO TID x 2 days
Pediatric Dosing
Dysuria
- 6-12yo: 4mg/kg PO TID x 2 days
- >12yo: 100-200mg PO TID x 2 days
Special Populations
- Pregnancy Rating: B, contraindicated in pyelonephritis during pregnancy
- Lactation risk: safety unknown, inadequate literature available; caution advised
Renal Dosing
- Adult:
- CrCl 50-80: give q12-16h
- CrCl<50: contraindicated
- Pediatric:
- CrCl 50-80: give q12-16h
- CrCl<50: contraindicated
Hepatic Dosing
- Adult:
- severe hepatitis: contraindicated
- Pediatric:
- severe hepatitis: contraindicated
Contraindications
- Allergy to class/drug
- glomerulonephritis
- severe hepatitis
- uremia
- pyelonephritis during pregnancy
- renal impairment
Adverse Reactions
Serious
- anaphylactoid reaction
- Methemoglobinemia
Common
- urine discoloration
- rash
- pruritis
- nausea
- headache
- dyspepsia
- anemia
- anaphylaxis
- contact lens staining
Pharmacology
- Half-life: unknown
- Metabolism: liver; CYP450
- Excretion: urine (65% unchanged)
- Mechanism of Action: produces topical analgesia