Captopril: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: ACE-inhibitor *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *6.25-150mg PO three times per day ==Pediatr...") |
ClaireLewis (talk | contribs) |
||
| Line 1: | Line 1: | ||
==Administration== | ==Administration== | ||
*Type: [[ACE | *Type: [[ACE inhibitor]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: | *Common Trade Names: | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 15:52, 8 September 2016
Administration
- Type: ACE inhibitor
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 6.25-150mg PO three times per day
Pediatric Dosing
Safety/efficacy not established in pediatric patients
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk minimal
- Renal dosing: Initial dose should be reduced, titrate in smaller increments
Contraindications
- Allergy to class/drug
- History of ACE-inhibitor induced angioedema
Adverse Reactions
Serious
- Angioedema
- Stevens-Johnson syndrome
- Agranulocytosis, neutropenia
Common
- Hypotension
- Hyperkalemia
- Cough
- Rash
Pharmacology
- Half-life: < 3 hours
- Metabolism:
- Excretion: Renal, dialzable
Mechanism of Action
- Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I--> angiotensin II