Myocarditis: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - " tach," to " tachycardia,") |
Neil.m.young (talk | contribs) (Text replacement - " ==" to "==") |
||
| Line 1: | Line 1: | ||
==Background == | ==Background== | ||
*Inflammatory cardiomyopathy (dilated cardiomyopathy) caused by necrosis of myocytes from infectious agents, their toxins, and cytotoxic effects of activated host immunity | *Inflammatory cardiomyopathy (dilated cardiomyopathy) caused by necrosis of myocytes from infectious agents, their toxins, and cytotoxic effects of activated host immunity | ||
*Majority caused by enterovirus (Cocksackie B) and adenovirus. Also influenza A/B, Hep B, B Hemolytic Streptococcus, Mycoplasma, Mumps, CMV and Toxoplasma (cardiac transplant), Chagas (leading cause worldwide) Trichinosis, Diphtheria, Lyme | *Majority caused by enterovirus (Cocksackie B) and adenovirus. Also influenza A/B, Hep B, B Hemolytic Streptococcus, Mycoplasma, Mumps, CMV and Toxoplasma (cardiac transplant), Chagas (leading cause worldwide) Trichinosis, Diphtheria, Lyme | ||
| Line 9: | Line 9: | ||
*Chronic: Diffuse myocardial fibrosis and cardiac dysfunction | *Chronic: Diffuse myocardial fibrosis and cardiac dysfunction | ||
==Clinical Features == | ==Clinical Features== | ||
*Typically young/few risk factors for CAD | *Typically young/few risk factors for CAD | ||
*[[Chest pain]] | *[[Chest pain]] | ||
| Line 31: | Line 31: | ||
*Endocardial biopsy: Gold standard | *Endocardial biopsy: Gold standard | ||
==Treatment == | ==Treatment== | ||
*Acute Phase: Antiviral agents may be effective with replicating virus: Pleconaril/Ribavirin | *Acute Phase: Antiviral agents may be effective with replicating virus: Pleconaril/Ribavirin | ||
*Subacute: Studies have not shown efficacy of immunosupressants. Peds: High dose IVIG | *Subacute: Studies have not shown efficacy of immunosupressants. Peds: High dose IVIG | ||
*Chronic: Treat CHF symptoms, Ventricular Assist Devices (VAD), cardiac transplant | *Chronic: Treat CHF symptoms, Ventricular Assist Devices (VAD), cardiac transplant | ||
==Disposition == | ==Disposition== | ||
*If [[CHF]]: Admit to monitored bed; ICU for hemodynamic instability | *If [[CHF]]: Admit to monitored bed; ICU for hemodynamic instability | ||
*Fulminant myocarditis has best prognosis | *Fulminant myocarditis has best prognosis | ||
| Line 47: | Line 47: | ||
*[[CHF]] | *[[CHF]] | ||
==See Also == | ==See Also== | ||
*[[Cardiomyopathy]] | *[[Cardiomyopathy]] | ||
*[[Pericarditis]] | *[[Pericarditis]] | ||
Revision as of 23:24, 3 August 2016
Background
- Inflammatory cardiomyopathy (dilated cardiomyopathy) caused by necrosis of myocytes from infectious agents, their toxins, and cytotoxic effects of activated host immunity
- Majority caused by enterovirus (Cocksackie B) and adenovirus. Also influenza A/B, Hep B, B Hemolytic Streptococcus, Mycoplasma, Mumps, CMV and Toxoplasma (cardiac transplant), Chagas (leading cause worldwide) Trichinosis, Diphtheria, Lyme
- Drugs: Doxorubicin, Cocaine
Phases
- Acute: Viral cytotoxicity and focal necrosis
- Subacute: Host's humoral/immune response leading to further cell injury
- Chronic: Diffuse myocardial fibrosis and cardiac dysfunction
Clinical Features
- Typically young/few risk factors for CAD
- Chest pain
- No sensitive symptom or sign but can have flu like syndrome: fever, fatigue, myalgia, nausea and vomiting; tachycardia (out of proportion to fever), tachypnea, new onset CHF
- In Peds: grunting, retractions, ronchi. Infants may have fulminant syndrome: Fever, cyanosis, respiratory distress, tachycardia, cardiac failure, ventricular dysrhythmias
- May have pericardial friction rub
- Consider this diagnosis in the septic-appearing patient who gets WORSE after receiving IV fluids.
Differential Diagnosis
- Acute MI
- Pericarditis
- CHF
Evaluation
- ECG: Sinus tachycardia, low voltages, prolonged QTc, AV block, Acute MI pattern (Usually >1 vessel distribution)
- TropI: Elevated
- Echo: Decreased LVEF, global hypokinesis, regional wall motion abnormalities
- Contrast MR
- Nuclear Study: Widespread uptake indicating myocyte necrosis
- Viral titers
- Endocardial biopsy: Gold standard
Treatment
- Acute Phase: Antiviral agents may be effective with replicating virus: Pleconaril/Ribavirin
- Subacute: Studies have not shown efficacy of immunosupressants. Peds: High dose IVIG
- Chronic: Treat CHF symptoms, Ventricular Assist Devices (VAD), cardiac transplant
Disposition
- If CHF: Admit to monitored bed; ICU for hemodynamic instability
- Fulminant myocarditis has best prognosis
- Mortality: 20% 1 yr/ 50% 5 yr
- Children with 70% survival rateat 5 yrs
Complications
- Ventricular dysrhythmias
- LV anneurysm
- CHF