Baclofen toxicity: Difference between revisions
(Text replacement - "N/V" to "nausea and vomiting") |
Neil.m.young (talk | contribs) (Text replacement - "==Diagnosis==" to "==Evaluation==") |
||
| Line 14: | Line 14: | ||
== | ==Evaluation== | ||
*Diagnosis of exclusion | *Diagnosis of exclusion | ||
Revision as of 23:03, 22 July 2016
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Clinical Features
- nausea and vomiting
- Drowziness, dizziness
- Seizures, delirium, AMS, coma
- Bradycardia, hypotension OR HTN, respiratory compromise
- Hypothermia
Differential Diagnosis
Evaluation
- Diagnosis of exclusion
Management
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82