Cimetidine: Difference between revisions

Revision as of 00:52, 20 July 2016

General

Type: H2 blocker
Dosage Forms: 200, 300, 400, 800mg
Common Trade Names: Tagamet HB 200

Adult Dosing

Duodenal Ulcer, Active: 800mg PO QHS x 4-8 weeks

Duodenal Ulcer, Maintenance: 400mg PO QHS

Gastric Ulcer, active benign: 800mg PO QHS x 6 weeks

H. Pylori Infection: 400mg PO BID x 10-28 days

Pediatric Dosing

GERD/PUD:

   *Neonates: 5- 10mg/kg/day PO divided q8-12h
   *Infants: 10-20mg/kg/day PO divided q8-12h
   *Children: 20-40mg/kg/day PO divided q6H

Special Populations

Pregnancy Rating: B (animal studies show no risk for adverse fetal effects, human fetal harm possible but unlikely)
Lactation: Probably Safe
Renal Dosing
- Adult: CrCL 10-50: decrease dose 50%, CrCl <10, decrease dose 75%
- Pediatric: CrCl 20-40, decrease dose 25% or give q8h, CrCL <20: decrease dose 50%
Hepatic Dosing
- Adult: Not Defined
- Pediatric not defined

Contraindications

Allergy to class/drug

- caution if renal impairment - caution if hepatic impairment - caution in elderly patients - caution if chronic pulmonary disease - caution if DM - caution if immunocompromised

Adverse Reactions

Serious

- neutropenia - thrombocytopenia - agranulocytosis - aplastic anemia - pneumonia -depression -psychosis -hallucinations -pancreatitis -interstital nephritis -bradycardia -tachycardia -AV block - skin reaction

Common

-headche -diarrhea -dizziness -gynecomastia -nausea -vomiting -confusion -agitation -drowsiness -rash -ALT,AST elevation

Pharmacology

Half-life: 2H
Metabolism: Liver; CYP450, 1A2, 2C19, 2D6 Inhibitor
Excretion: urine
Mechanism of Action: Histamine H2 Receptor blocker

References

Authors:

@@ Line 1: / Line 1: @@
 ==General==
 *Type: [[H2 blocker]]
-*Dosage Forms: 200, 300, 400, 800 mg
+*Dosage Forms: 200, 300, 400, 800mg
 *Common Trade Names: Tagamet HB 200
 ==Adult Dosing==
-Duodenal Ulcer, Active: 800 mg PO QHS x 4-8 weeks
+Duodenal Ulcer, Active: 800mg PO QHS x 4-8 weeks
-Duodenal Ulcer, Maintenance: 400 mg PO QHS
+Duodenal Ulcer, Maintenance: 400mg PO QHS
-Gastric Ulcer, active benign: 800 mg PO QHS x 6 weeks
+Gastric Ulcer, active benign: 800mg PO QHS x 6 weeks
-H. Pylori Infection: 400 mg PO BID x 10-28 days
+H. Pylori Infection: 400mg PO BID x 10-28 days
 ==Pediatric Dosing==
@@ Line 18: / Line 18: @@
 GERD/PUD:
-     *Neonates: 5- 10 mg/kg/day PO divided q8-12h
+     *Neonates: 5- 10mg/kg/day PO divided q8-12h
-     *Infants: 10-20 mg/kg/day PO divided q8-12h
+     *Infants: 10-20mg/kg/day PO divided q8-12h
-     *Children: 20-40 mg/kg/day PO divided q6H
+     *Children: 20-40mg/kg/day PO divided q6H
 ==Special Populations==