|
|
| Line 1: |
Line 1: |
| === Overview table ===
| |
|
| |
|
| {| class="wikitable"
| |
| |-
| |
| ! Class
| |
| ! Known as
| |
| ! Examples
| |
| ! Mechanism
| |
| ! Clinical uses
| |
| |-
| |
| ! Ia
| |
| | fast-channel blockers-Affect QRS complex
| |
| |
| |
| *Quinidine
| |
| *Procainamide
| |
| *Disopyramide
| |
|
| |
| | (Na<sup>+</sup>) channel block (intermediate association/dissociation)
| |
| |
| |
| *Ventricular arrhythmias
| |
| *prevention of paroxysmal Recurrent atrial fibrillation (triggered by Vagus nerve overactivity)
| |
| *procainamide in [[Wolf Parkinson White (WPW)]]
| |
|
| |
| |-
| |
| ! Ib- Do not affect QRS complex
| |
| |
| |
| |
| |
| *Lidocaine
| |
| *Phenytoin
| |
| *Mexiletine
| |
| *Tocainide
| |
|
| |
| | (Na<sup>+</sup>) channel block (fast association/dissociation)
| |
| |
| |
| *treatment and prevention during and immediately after Myocardial infarction, though this practice is now discouraged given the increased risk of Asystole
| |
| *Ventricular tachycardia
| |
| *[[Atrial_Fibrillation_(Main)|Atrial fibrillation]]
| |
|
| |
| |-
| |
| ! Ic
| |
| |
| |
| |
| |
| *Flecainide
| |
| *Propafenone
| |
| *Moricizine
| |
|
| |
| | (Na<sup>+</sup>) channel block (slow association/dissociation)
| |
| |
| |
| *prevents Paroxysmal atrial fibrillation
| |
| *treats Recurrent tachyarrhythmias of abnormal conduction system.
| |
| *contraindicated immediately post-myocardial infarction.
| |
|
| |
| |-
| |
| ! II
| |
| | Beta-blockers
| |
| |
| |
| *Propranolol
| |
| *Esmolol
| |
| *Timolol
| |
| *Metoprolol
| |
| *Atenolol
| |
| *Bisoprolol
| |
|
| |
| | beta blocking<br>Propranolol also shows some class I action
| |
| |
| |
| *decrease Myocardial infarction mortality
| |
| *prevent recurrence of Tachyarrhythmias
| |
|
| |
| |-
| |
| ! III
| |
| |
| |
| |
| |
| *Amiodarone
| |
| *Sotalol
| |
| *Ibutilide
| |
| *Dofetilide
| |
| *Dronedarone
| |
| *E-4031
| |
|
| |
| |
| |
| K<sup>+</sup> channel blocker
| |
|
| |
| Sotalol is also a beta blocker
| |
|
| |
| Amiodarone has Class I, II, and III activity
| |
|
| |
| |
| |
| *In [[Wolf Parkinson White (WPW)]]
| |
| *(sotalol:) Ventricular tachycardias and Atrial fibrillation
| |
| *(Ibutilide:) Atrial flutter and [[Atrial_Fibrillation_(Main)|Atrial fibrillation]]
| |
|
| |
| |-
| |
| ! IV
| |
| | slow-channel blockers
| |
| |
| |
| *Verapamil
| |
| *Diltiazem
| |
|
| |
| | Ca<sup>2+</sup> channel blocker
| |
| |
| |
| *prevent recurrence of Paroxysmal supraventricular tachycardia
| |
| *reduce Ventricular rate in patients with [[Atrial_Fibrillation_(Main)|Atrial fibrillation]]
| |
|
| |
| |-
| |
| ! V
| |
| |
| |
| |
| |
| *Adenosine
| |
| *Digoxin
| |
| *Magnesium Sulfate
| |
|
| |
| | Work by other or unknown mechanisms (Direct nodal inhibition).
| |
| |
| |
| Used in supraventricular arrhythmias,
| |
|
| |
| Or in the case of Magnesium Sulfate, used in Torsade de Pointe.
| |
|
| |
| |}
| |
|
| |
| == Source ==
| |
|
| |
| UpToDate
| |
|
| |
| Katzung & Trevor's Pharmacology
| |
|
| |
| [[Category:Cards]]
| |