Pralidoxime: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
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*1-2gm IV over 5-10min | *1-2gm IV over 5-10min | ||
*Continuous infusion of 500mg/hr if no initial response | *Continuous infusion of 500mg/hr if no initial response | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Line 30: | Line 29: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Tachycardia | |||
*Hypertension | |||
*Laryngospasm | |||
*Hepatitis | |||
===Common=== | ===Common=== | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: Apparent: 74 to 77 minutes, IM/IV exposure: 3 to 4 hours | ||
*Metabolism: | *Metabolism: Hepatic | ||
*Excretion: | *Excretion: | ||
*Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early) | *Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early before irreversible enzyme binding occurs, aka "aging") | ||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
[[Organophosphate Toxicity]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Revision as of 16:37, 20 July 2016
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Organophosphate toxicity
- 1-2gm IV over 5-10min
- Continuous infusion of 500mg/hr if no initial response
Pediatric Dosing
Organophosphate toxicity
- 20-40mg/kg (up to 1gm) IV over 5-10min
- 5-10mg/kg/hr if no initial response
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Tachycardia
- Hypertension
- Laryngospasm
- Hepatitis
Common
Pharmacology
- Half-life: Apparent: 74 to 77 minutes, IM/IV exposure: 3 to 4 hours
- Metabolism: Hepatic
- Excretion:
- Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early before irreversible enzyme binding occurs, aka "aging")