Calcium gluconate: Difference between revisions
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***1-2 g IV over 2 hours | ***1-2 g IV over 2 hours | ||
**Severe (Calcium < 1 mmol/L) | **Severe (Calcium < 1 mmol/L) | ||
***without seizure or tetany: 0.5 mg/kg/hr IV, may be increased to | ***without seizure or tetany: 0.5 mg/kg/hr IV, may be increased to 2mg/kg/hr | ||
***Hypocalcemic tetany: | ***Hypocalcemic tetany: | ||
****100-300 mg elemental calcium (~3g calcium gluconate) IV over 5-10 min | ****100-300 mg elemental calcium (~3g calcium gluconate) IV over 5-10 min | ||
Revision as of 03:37, 19 July 2016
General
- Type:
- Dosage Forms: IV/PO
- Common Trade Names: Calcium Gluconate
Adult Dosing
- Calcium Supplementation
- 19-50 years old: 1000 mg/day PO (divided q8-12hr)
- >50 years old: 1200 mg/day PO (divided q8-12hr)
- Pregnant or breastfeeding patient: 1000 mg/day PO (divided q8-12hr)
- Hypocalcemia
- Mild (Calcium 1-1.2 mmol/L)
- 1-3 g/day PO in divided doses
- 1-2 g IV over 2 hours
- Severe (Calcium < 1 mmol/L)
- without seizure or tetany: 0.5 mg/kg/hr IV, may be increased to 2mg/kg/hr
- Hypocalcemic tetany:
- 100-300 mg elemental calcium (~3g calcium gluconate) IV over 5-10 min
- Followed by continuous IV infusion at 0.5 mg/kg/hr
- Mild (Calcium 1-1.2 mmol/L)
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation risk: Use with caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Hypersensitivity
- Hypercalcemia
- Digoxin poisoning
Adverse Reactions
- Frequency not defined
- Bradycardia
- Constipation
- Headache
Pharmacology
- Half-life:
- Metabolism:
- Absorption requires Vitamin D
- Absorption is increased with acidic condition; thus, administer 1-2 hr after meals
- ~45% protein bound (primarily to albumin)
- Excretion: Feces (80%), Urine (20%)
- Mechanism of Action: Bone mineral component; cofactor in enzymatic reactions, essential for neurotrasmission, muscle contraction, and many signal transduction pathways.