Oxcarbazepine: Difference between revisions
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*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: CrCl <30: start 150 mg bid; HD/PD: no supplement; Info: titrate dose slowly until response | ||
*Pediatric: | *Pediatric: | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: mild-mod impairment: no adjustment; severe impairment: not defined | ||
*Pediatric: | *Pediatric: | ||
Revision as of 23:24, 10 February 2016
Administration
- Type: anti epileptic
- Dosage Forms: 150,300,600; 300/5 mL
- Routes of Administration: PO
- Common Trade Names: Trileptal
Adult Dosing
Partial seizures
- adjunct tx: Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day;
- conversion to monotherapy: Dose: 1200 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day; D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C
- initial monotherapy: Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by 300 mg/day q3 days; Max: 2400 mg/day
Trigeminal neuralgia
- 450-1200 mg PO bid
- Start: 300 mg PO bid, may incr. by 600 mg/day qwk
Bipolar disorder
- 600-1200 mg PO bid
- Start: 300 mg PO bid, incr. by 300 mg/day q3 days or by 600 mg/day qwk
Pediatric Dosing
Special Populations
Renal Dosing
- Adult: CrCl <30: start 150 mg bid; HD/PD: no supplement; Info: titrate dose slowly until response
- Pediatric:
Hepatic Dosing
- Adult: mild-mod impairment: no adjustment; severe impairment: not defined
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: