Template:Digoxin mechanism: Difference between revisions
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*Inhibits Na+/K+ ATPase in the myocardium<ref>Gheorghiade M. et al. Digoxin in the Management of Cardiovascular Disorders. Circulation. 2004; 109: 2959-2964</ref> | *Inhibits Na+/K+ ATPase in the myocardium<ref>Gheorghiade M. et al. Digoxin in the Management of Cardiovascular Disorders. Circulation. 2004; 109: 2959-2964</ref> | ||
**Causes increase in intracellular sodium levels | **Causes increase in intracellular sodium levels | ||
**Results in reversal of sodium-calcium exchanger | **Results in reversal of sodium-calcium exchanger | ||
***Normally imports three extracellular sodium ions into the cardiac myocyte in exchange for one intracellular calcium being exported | |||
**Sodium accumulates intracellularly and is exchanged for Calcium. | **Sodium accumulates intracellularly and is exchanged for Calcium. | ||
**Causes an increase in the intracellular calcium concentration increasing contractility | **Causes an increase in the intracellular calcium concentration increasing contractility | ||
Latest revision as of 22:30, 12 September 2015
- Inhibits Na+/K+ ATPase in the myocardium[1]
- Causes increase in intracellular sodium levels
- Results in reversal of sodium-calcium exchanger
- Normally imports three extracellular sodium ions into the cardiac myocyte in exchange for one intracellular calcium being exported
- Sodium accumulates intracellularly and is exchanged for Calcium.
- Causes an increase in the intracellular calcium concentration increasing contractility
- Also a lengthening of phase 4 and phase 0 of the cardiac action potential which ultimately decreases heart rate
- Summary
- Inhibits NaK pump
- Positive inotropy
- Negative chronotropy/dromotropy
- Indirect vagal stimulator
- Inhibits NaK pump
- ↑ Gheorghiade M. et al. Digoxin in the Management of Cardiovascular Disorders. Circulation. 2004; 109: 2959-2964