Metoclopramide: Difference between revisions
| Line 27: | Line 27: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 5-6h | ||
*Metabolism: | *Metabolism: liver minimally; CYP450: unknown | ||
*Excretion: | *Excretion: urine 85% (20% unchanged), bile/feces 5% | ||
*Mechanism of Action: | *Mechanism of Action: exact mechanism of action unknown; sensitizes tissues to acetylcholine, stimulating upper GI tract motility; antagonizes central and peripheral dopamine receptors, producing antiemetic effects | ||
==Comments== | ==Comments== | ||
Revision as of 20:21, 30 June 2015
General
- Type: anti-emetic
- Dosage Forms: 5, 10; 5/5 mL; IM; IV
- Common Trade Names: Reglan
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 5-6h
- Metabolism: liver minimally; CYP450: unknown
- Excretion: urine 85% (20% unchanged), bile/feces 5%
- Mechanism of Action: exact mechanism of action unknown; sensitizes tissues to acetylcholine, stimulating upper GI tract motility; antagonizes central and peripheral dopamine receptors, producing antiemetic effects