Atenolol

General

• Type: Beta blocker
• Dosage Forms: PO
• Common Trade Names: Tenormin

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug
• sinus bradycardia
• 2nd or 3rd degree AV block
• heart failure, uncompensated
• cardiogenic shock
• sick sinus syndrome w/o pacemaker
• pheochromocytoma, untreated
• avoid abrupt withdrawal
• caution if peripheral vascular dz
• caution if bronchospastic dz
• caution if major surgery
• caution if diabetes mellitus
• caution if thyroid disorder
• caution if WPW syndrome
• caution if renal impairment
• caution if pregnancy
• caution if breastfeeding
• caution if myasthenia gravis
• caution if severe anaphylactic rxn hx
• caution in elderly pts

Adverse Reactions

Serious

• CHF
• bradycardia, severe
• heart block
• angina exacerbation if abrupt D/C
• MI if abrupt D/C
• ventricular arrhythmia during tx and if abrupt D/C
• Raynaud phenomenon
• bronchospasm
• hypersensitivity rxn
• lupus erythematosus

Common

• bradycardia
• hypotension
• fatigue
• dizziness
• cold extremities
• depression
• dyspnea
• hypotension, orthostatic
• leg pain
• bronchospasm
• lightheadedness
• lethargy
• diarrhea
• nausea
• vertigo
• drowsiness

Pharmacology

• Half-life: 6-7h
• Metabolism: CYP450
• Excretion: urine 40-50%, feces 50%
• Mechanism of Action: selectively antagonizes beta-1 adrenergic receptors