Hydrocortisone topical: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: Excretion in milk unknown; use with caution | ||
*Renal Dosing | *Renal Dosing: None | ||
*Hepatic Dosing: None | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
Revision as of 09:41, 31 July 2015
General
- Type: Topical steroid
- Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
- Common Trade Names: Cortizone, Cortaid, Hytone, Texacort
Adult Dosing
dermatoses, steroid-responsive: apply bid-qid
Pediatric Dosing
dermatoses, steroid-responsive: apply bid-qid
Special Populations
- Pregnancy Rating: C
- Lactation: Excretion in milk unknown; use with caution
- Renal Dosing: None
- Hepatic Dosing: None
Contraindications
- Allergy to class/drug
- caution if skin infection
- caution in pediatric pts
Adverse Reactions
Serious
- HPA axis suppresion
- Cushing syndrome
- hyperglycemia
- intracranial HTN (peds pts)
Common
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Pharmacology
- Half-life: 8-12h
- Metabolism: liver primarily; CYP450
- Excretion: urine
- Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects