Digoxin: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
''[[Digoxin toxicity]]'' | |||
*GI: N/V, diarrhea, abd pain | *GI: N/V, diarrhea, abd pain | ||
*CV: Bradycardia, SA/AV block, ventr arrhythmias | *CV: Bradycardia, SA/AV block, ventr arrhythmias | ||
Revision as of 13:23, 10 June 2015
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Loading dose = 0.25 mg IV q2hr until effect (max total = 1.5 mg)
- in acute afib rvr with heart failure = 0.5 mg IV, then 0.25 mg IV q4hr until effect or max 1.5mg
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- RVR control in a-fib/flutter, PSVT
Contraindications
- Allergy to class/drug
- WPW
- Increases conduction velocity in atrial tissue
Adverse Reactions
- GI: N/V, diarrhea, abd pain
- CV: Bradycardia, SA/AV block, ventr arrhythmias
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
- Inhibits NaK pump
- Positive inotropy
- Negative chronotropy/dromotropy
- Indirect vagal stimulator
- Inhibits NaK pump
- Kinetics
- Onset of action = 1.5-4hr (IV)