Alprazolam: Difference between revisions
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[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 17:50, 29 May 2015
General
- Type: Benzodiazepines
- Dosage Forms: ODT Immediate Release - 0.25, 0.5, 1, 2 mg tablets. Extended Release - 0.5, 1, 2, 3mg tablets, Oral liquid, 1mg/mL
- Common Trade Names: Xanax
Adult Dosing
Anxiety 0.25-0.5mg PO TID, Max: 4mg/day
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing: no adjustment
- Hepatic Dosing:
- Adult: start at min dose, slowly uptitrate dose amount and frequency to max of 4mg/day
Contraindications
- Allergy to class/drug
- Sleep apnea
- Concomitant Alcohol use
- Concominant CNS depressant use
- Elderly
- Abuse history
- Hepatic disease (decreased clearance)
Adverse Reactions
Serious
- Respiratory depression/arrest
- Abuse
- Hypotension
- Syncope
- Hepatotoxicity
- Angioedema
- Steven-Johnson Syndrome
Common
- Altered mental status (drowsiness, fatigue, amnesia, impaired concentration, impaired coordination)
- Urinary incontinence/retention
Pharmacology
- Half-life:
- Metabolism: Hepatic via CYP450:3A4 substrate
- Excretion: Urine
- Mechanism of Action: Enhances GABA effects by binding to specific benzodiazepine receptor
See Also
Sources