Colestipol: Difference between revisions

Latest revision as of 12:34, 7 January 2026

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Administration

Type: Bile Acid Binder
Dosage Forms: 1 g tab; 5 g/scoop granules; 5 g granule packet
Routes of Administration: Oral
Common Trade Names: N/A

Adult Dosing

Digoxin toxicity, adjunct tx
- Granules: 5 g PO q6-8h
  - Start: 10 g PO x1 within 1-3h after last oral digoxin ingestion
  - Max: 30 g/day
Gallbladder surgery-associated diarrhea, adjunct tx
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day
Hypercholesterolemia
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day
Pruritus secondary to biliary obstruction
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day

Pediatric Dosing

Pediatric dosing currently unavailable.

Special Populations

Pregnancy Rating: C; Inadequate data to assess risk
Lactation risk: L3; Safety unknown

Renal Dosing

Adult: No adjustment
Pediatric: N/A

Hepatic Dosing

Adult: Not defined.
Pediatric: N/A

Contraindications

Allergy to class/drug
Caution if constipation
Caution if prolonged use

Adverse Reactions

Serious

Fecal impaction
PUD
Cholecystitis
Cholelithiasis
Esophageal obstruction

Common

Constipation
Abdominal pain
Abdominal cramps
Abdominal distention
Flatulence
Dyspepsia
Loose stool/Diarrhea
Nausea/Vomiting
ALT, AST elevation
Alk Phos. elevation
Bleeding hemorrhoids

Pharmacology

Half-life: Unknown
Metabolism: N/A
Excretion: Feces

Mechanism of Action

Binds intestinal bile acids for excretion.

Comments

References

Authors:

@@ Line 2: / Line 2: @@
 <translate>
-==Administration==
+==Administration== <!--T:1-->
+<!--T:2-->
 *Type: Bile Acid Binder
 *Dosage Forms: 1 g tab; 5 g/scoop granules; 5 g granule packet
@@ Line 10: / Line 11: @@
-==Adult Dosing==
+==Adult Dosing== <!--T:3-->
+<!--T:4-->
 *[[Special:MyLanguage/Digoxin toxicity|Digoxin toxicity]], adjunct tx
 **Granules: 5 g PO q6-8h
@@ Line 42: / Line 44: @@
-==Pediatric Dosing==
+==Pediatric Dosing== <!--T:5-->
+<!--T:6-->
 Pediatric dosing currently unavailable.
-==Special Populations==
+==Special Populations== <!--T:7-->
+<!--T:8-->
 *[[Special:MyLanguage/Drug pregnancy categories|Pregnancy Rating]]: C; Inadequate data to assess risk
 *Lactation risk: L3; Safety unknown
-===Renal Dosing===
+===Renal Dosing=== <!--T:9-->
+<!--T:10-->
 *Adult: No adjustment
 *Pediatric: N/A
-===Hepatic Dosing===
+===Hepatic Dosing=== <!--T:11-->
+<!--T:12-->
 *Adult: Not defined.
 *Pediatric: N/A
-==Contraindications==
+==Contraindications== <!--T:13-->
+<!--T:14-->
 *Allergy to class/drug
 *Caution if constipation
@@ Line 71: / Line 78: @@
-==Adverse Reactions==
+==Adverse Reactions== <!--T:15-->
-===Serious===
+===Serious=== <!--T:16-->
+<!--T:17-->
 *Fecal impaction
 *[[Special:MyLanguage/PUD|PUD]]
@@ Line 83: / Line 91: @@
-===Common===
+===Common=== <!--T:18-->
+<!--T:19-->
 *[[Special:MyLanguage/Constipation|Constipation]]
 *Abdominal pain
@@ Line 98: / Line 107: @@
-==Pharmacology==
+==Pharmacology== <!--T:20-->
+<!--T:21-->
 *Half-life: Unknown
 *Metabolism: N/A
@@ Line 105: / Line 115: @@
-==Mechanism of Action==
+==Mechanism of Action== <!--T:22-->
+<!--T:23-->
 Binds intestinal bile acids for excretion.
-==Comments==
+==Comments== <!--T:24-->
-==See Also==
+==See Also== <!--T:25-->
+<!--T:26-->
 [[Special:MyLanguage/Digoxin toxicity|Digoxin toxicity]]
-==References==
+==References== <!--T:27-->
+<!--T:28-->
 <references/>
+<!--T:29-->
 [[Category:Pharmacology]]
 [[Category:GI]]
 [[Category:Toxicology]]
 </translate>