Metabolic dysfunction-associated steatohepatitis (MASH): Difference between revisions
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[[File:Stage of liver damage high.jpg|thumb|Stages of non-alcoholic fatty liver disease, progressing from healthy, to steatosis (fat accumulation), inflammation, fibrosis and cirrhosis.]] | [[File:Stage of liver damage high.jpg|thumb|Stages of non-alcoholic fatty liver disease, progressing from healthy, to steatosis (fat accumulation), inflammation, fibrosis and cirrhosis.]] | ||
[[File:Sobo 1906 389.png|thumb|Inferior view of the liver with surface showing lobes and impressions.]] | [[File:Sobo 1906 389.png|thumb|Inferior view of the liver with surface showing lobes and impressions.]] | ||
[[File:Liver vascular anatomy.png|thumb|Liver vascular anatomy.]] | |||
*Fatty liver disease due to causes other than excessive alcohol | *Fatty liver disease due to causes other than excessive alcohol | ||
*Associated with insulin resistance and [[metabolic syndrome]] | *Associated with insulin resistance and [[metabolic syndrome]] | ||
Revision as of 23:03, 13 November 2024
Background
- Fatty liver disease due to causes other than excessive alcohol
- Associated with insulin resistance and metabolic syndrome
Clinical Features
- Often asymptomatic or with mild RUQ discomfort
- Signs of portal hypertension (e.g. ascites) if advanced fibrosis
- Hepatomegaly
Differential Diagnosis
Hepatic Dysfunction
Infectious
- Hepatitis
- Malaria
- HIV (present in 50% of AIDS patients)[1]
- EBV
- Babesiosis, leptospirosis
- Typhoid
- Hepatic abscess, amebiasis
Neoplastic
Metabolic
Biliary
- Biliary cirrhosis
Drugs
- Alcoholic cirrhosis
- Alcoholic hepatitis
- Hepatotoxic drugs
Miscellaneous
- Other causes of cirrhosis
- Autoimmune hepatitis
- Veno-occlusive disease
- CHF (right heart failure)
Evaluation
Management
- Treat complications of portal hypertension, if present
- Counsel on weight loss, increased coffee consumption
- Vitamin E if known F2 fibrosis
Disposition
- Discharge unless complications
See Also
External Links
References
- ↑ Tintanelli's