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| *[[Acute myeloid leukemia]] | | *[[Acute myeloid leukemia]] |
| *[[Acute lymphocytic leukemia]] | | *[[Acute lymphocytic leukemia]] |
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| === Background ===
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| *Characterized by proliferation of immature lymphoblast( >20% in periphery)
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| *Less than 20% of acute leukemias in adults,
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| *Most common form in children (see also [[Leukemia (Peds)]])
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| *Highest incidence in 7th decade of life
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| === Diagnosis ===
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| *Lymphocytosis, neutropenia, anemia, thrombocytopenia,
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| *Lymphadenopathy, hepatosplenomegaly
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| *CNS and testes involvement common
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| === DDX ===
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| *Hodgkin and non-Hodgkin lymphomas
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| === Work-Up ===
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| *CXR
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| *CBC with peripheral smear
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| *Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
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| *LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
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| *Get extra purple top for flow cytometry, especially before transfusion
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| === Treatment ===
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| *Aggressive IV hydration
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| *If febrile, complete cultures and broad spectrum antibiotics
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| *Manage Complications
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| **see [[DIC]]
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| **see [[Leukostasis]]
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| **see [[Tumor Lysis Syndrome]]
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| <br>
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| == Source ==
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| Uptodate & MKSAP15
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| == See Also == | | == See Also == |
