Ondansteron: Difference between revisions
(added page) |
(added page) |
||
| Line 5: | Line 5: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Nausea/Vomiting: 4-8 mg q4h, max 24 mg a day | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Nausea/Vomiting: 0.1 mg/kg IV q4h max dose at once:4-8 mg, max 24 mg | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:B | ||
*Lactation: | *Lactation:safety unknown | ||
*Renal Dosing | **Adult: | ||
* | *Renal Dosing:not defined | ||
**Pediatric | *Hepatic Dosing: not defined | ||
*Hepatic Dosing | **Pediatric: | ||
* | *Hepatic Dosing: not defined | ||
*Renal Dosing:not defined | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*congenital long QT syndrome | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*bronchospasm | |||
*steven-johnson syndrome | |||
*QT prolongation | |||
*torsades de pointes | |||
*serotonin syndrome | |||
*extrapyramidal SX | |||
*blindness, transient | |||
===Common=== | ===Common=== | ||
*headache | |||
*constipation | |||
*fatigue | |||
*hypoxia | |||
*fever | |||
*urinary retention | |||
*agitation | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 4.6-5.7 hour | ||
*Metabolism: | *Metabolism: liver | ||
*Excretion: | *Excretion: urine | ||
*Mechanism of Action: | *Mechanism of Action:selectively antagonizes serotonin 5-HT3 receptors | ||
==See Also== | ==See Also== | ||
Revision as of 10:10, 13 April 2015
General
- Type: anti-emetic
- Dosage Forms:4, 8
- Common Trade Names: Zofran
Adult Dosing
- Nausea/Vomiting: 4-8 mg q4h, max 24 mg a day
Pediatric Dosing
- Nausea/Vomiting: 0.1 mg/kg IV q4h max dose at once:4-8 mg, max 24 mg
Special Populations
- Pregnancy Rating:B
- Lactation:safety unknown
- Adult:
- Renal Dosing:not defined
- Hepatic Dosing: not defined
- Pediatric:
- Hepatic Dosing: not defined
- Renal Dosing:not defined
Contraindications
- Allergy to class/drug
- congenital long QT syndrome
Adverse Reactions
Serious
- bronchospasm
- steven-johnson syndrome
- QT prolongation
- torsades de pointes
- serotonin syndrome
- extrapyramidal SX
- blindness, transient
Common
- headache
- constipation
- fatigue
- hypoxia
- fever
- urinary retention
- agitation
Pharmacology
- Half-life: 4.6-5.7 hour
- Metabolism: liver
- Excretion: urine
- Mechanism of Action:selectively antagonizes serotonin 5-HT3 receptors