Alprazolam: Difference between revisions
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==General== | ==General== | ||
*Type: [[Benzodiazepines]] | *Type: [[Benzodiazepines]] | ||
*Dosage Forms: | *Dosage Forms: ODT Immediate Release - 0.25, 0.5, 1, 2 mg tablets. Extended Release - 0.5, 1, 2, 3mg tablets, Oral liquid, 1mg/mL | ||
*Common Trade Names: Xanax | *Common Trade Names: Xanax | ||
==Adult Dosing== | ==Adult Dosing== | ||
Anxiety 0.25-0.5mg PO TID, Max: 4mg/day | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | ||
*Lactation: | *Lactation: | ||
*Renal Dosing | *Renal Dosing: no adjustment | ||
*Hepatic Dosing: | |||
*Hepatic Dosing | **Adult: start at min dose, slowly uptitrate dose amount and frequency to max of 4mg/day | ||
**Adult | ** | ||
** | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Sleep apnea | |||
*Concomitant Alcohol use | |||
*Concominant CNS depressant use | |||
*Elderly | |||
*Abuse history | |||
*Hepatic disease (decreased clearance) | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Respiratory depression/arrest | |||
*Abuse | |||
*Hypotension | |||
*Syncope | |||
*Hepatotoxicity | |||
*Angioedema | |||
*Steven-Johnson Syndrome | |||
===Common=== | ===Common=== | ||
*Altered mental status (drowsiness, fatigue, amnesia, impaired concentration, impaired coordination) | |||
*Urinary incontinence/retention | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: | ||
*Metabolism: | *Metabolism: Hepatic via CYP450:3A4 substrate | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: Enhances GABA effects by binding to specific benzodiazepine receptor | ||
==See Also== | ==See Also== | ||
Revision as of 00:20, 29 May 2015
General
- Type: Benzodiazepines
- Dosage Forms: ODT Immediate Release - 0.25, 0.5, 1, 2 mg tablets. Extended Release - 0.5, 1, 2, 3mg tablets, Oral liquid, 1mg/mL
- Common Trade Names: Xanax
Adult Dosing
Anxiety 0.25-0.5mg PO TID, Max: 4mg/day
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing: no adjustment
- Hepatic Dosing:
- Adult: start at min dose, slowly uptitrate dose amount and frequency to max of 4mg/day
Contraindications
- Allergy to class/drug
- Sleep apnea
- Concomitant Alcohol use
- Concominant CNS depressant use
- Elderly
- Abuse history
- Hepatic disease (decreased clearance)
Adverse Reactions
Serious
- Respiratory depression/arrest
- Abuse
- Hypotension
- Syncope
- Hepatotoxicity
- Angioedema
- Steven-Johnson Syndrome
Common
- Altered mental status (drowsiness, fatigue, amnesia, impaired concentration, impaired coordination)
- Urinary incontinence/retention
Pharmacology
- Half-life:
- Metabolism: Hepatic via CYP450:3A4 substrate
- Excretion: Urine
- Mechanism of Action: Enhances GABA effects by binding to specific benzodiazepine receptor