Glucagon: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Beta-blocker toxicity]]=== | ===[[Beta-blocker toxicity]]<ref name="KernsEMC">Kerns W. Management of beta-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am. 2007;25(2):309-331. (Review)</ref> <ref>Bailey B (2003). Glucagon in beta-blocker and calcium channel blocker overdoses: a systematic review. Journal of toxicology. Clinical toxicology, 41 (5), 595-602 PMID: 14514004</ref>=== | ||
* | *5mg IV bolus over one minute | ||
** | *Rebolus if no response after 10min | ||
*If effective, start infusion at 2-5mg/hr | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===[[Beta-blocker toxicity]] <ref name="KernsEMC" />=== | |||
*Ped: 50mcg/kg | |||
*Rebolus if no response after 10min | |||
*If effective, start infusion at 70mcg/kg/hr | |||
==Special Populations== | ==Special Populations== | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 20 minutes | ||
*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: | ||
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<references/> | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
*Consider concurrent administration of ondansetron (causes n/v) | |||
*Rebolus if no response after 10min | |||
*Effects persist for 10-15 min | |||
*If effective start infusion at: | |||
**Adult: 2-5mg/hr | |||
**Ped: 70mcg/kg/hr | |||
Revision as of 18:24, 8 March 2015
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Beta-blocker toxicity[1] [2]
- 5mg IV bolus over one minute
- Rebolus if no response after 10min
- If effective, start infusion at 2-5mg/hr
Pediatric Dosing
Beta-blocker toxicity [1]
- Ped: 50mcg/kg
- Rebolus if no response after 10min
- If effective, start infusion at 70mcg/kg/hr
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 20 minutes
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Sources
- ↑ 1.0 1.1 Kerns W. Management of beta-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am. 2007;25(2):309-331. (Review)
- ↑ Bailey B (2003). Glucagon in beta-blocker and calcium channel blocker overdoses: a systematic review. Journal of toxicology. Clinical toxicology, 41 (5), 595-602 PMID: 14514004
- Consider concurrent administration of ondansetron (causes n/v)
- Rebolus if no response after 10min
- Effects persist for 10-15 min
- If effective start infusion at:
- Adult: 2-5mg/hr
- Ped: 70mcg/kg/hr