Template:Table of severe drug reactions: Difference between revisions
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| align="center" style="background:#f0f0f0;"|'''[[Erythroderma]]''' | | align="center" style="background:#f0f0f0;"|'''[[Erythroderma]]''' | ||
|- | |- | ||
| Onset of eruption||2-6 weeks||1-3 weeks||48 hours||1-3 weeks | | '''Onset of eruption'''||2-6 weeks||1-3 weeks||48 hours||1-3 weeks | ||
|- | |- | ||
| Duration of eruption (weeks)||Several||1-3||<1||Several | | '''Duration of eruption (weeks)'''||Several||1-3||<1||Several | ||
|- | |- | ||
| Fever||+++||+++||+++||+++ | | '''Fever'''||+++||+++||+++||+++ | ||
|- | |- | ||
| Mucocutaneous features||Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions||Bullae, atypical target lesions, mucocutaneous erosions||Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement||Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation | | '''Mucocutaneous features'''||Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions||Bullae, atypical target lesions, mucocutaneous erosions||Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement||Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation | ||
|- | |- | ||
| Lymph node enlargement||+++||-||+||+ | | '''Lymph node enlargement'''||+++||-||+||+ | ||
|- | |- | ||
| Neutrophils||Elevated||Decreased||Very elevated||Elevated | | '''Neutrophils'''||Elevated||Decreased||Very elevated||Elevated | ||
|- | |- | ||
| Eosinophils||Very elevated||No change||Elevated||Elevated | | '''Eosinophils'''||Very elevated||No change||Elevated||Elevated | ||
|- | |- | ||
| Atypical lymphocytes||+||-||-||+ | | '''Atypical lymphocytes'''||+||-||-||+ | ||
|- | |- | ||
| Hepatitis||+++||++||++||- | | '''Hepatitis'''||+++||++||++||- | ||
|- | |- | ||
| Other organ involvement||Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis||Tubular nephritis and tracheobronical necrosis||Possible||Possible | | '''Other organ involvement'''||Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis||Tubular nephritis and tracheobronical necrosis||Possible||Possible | ||
|- | |- | ||
| Histological pattern of skin||Perivascular lymphocytcic infiltrate||Epidermal necrosis||Subcorneal pustules||Nonspecific, unless reflecting Sezary syndrome or other lymphoma | | '''Histological pattern of skin'''||Perivascular lymphocytcic infiltrate||Epidermal necrosis||Subcorneal pustules||Nonspecific, unless reflecting Sezary syndrome or other lymphoma | ||
|- | |- | ||
| Lymph node histology||Lymphoid hyperplasia||-||-||No, unless reflecting Sezary syndrome or other malignancy | | '''Lymph node histology'''||Lymphoid hyperplasia||-||-||No, unless reflecting Sezary syndrome or other malignancy | ||
|- | |- | ||
| Mortality (%)||10||5-35||5||5-15 | | '''Mortality''' (%)||10||5-35||5||5-15 | ||
|} | |} | ||
;AGEP Acute generalized exanthematous pustulosis | ;AGEP Acute generalized exanthematous pustulosis | ||
Revision as of 19:15, 17 December 2019
Table of Severe Drug Reactions
| Charateristic | DRESS | SJS/TEN | AGEP | Erythroderma |
| Onset of eruption | 2-6 weeks | 1-3 weeks | 48 hours | 1-3 weeks |
| Duration of eruption (weeks) | Several | 1-3 | <1 | Several |
| Fever | +++ | +++ | +++ | +++ |
| Mucocutaneous features | Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions | Bullae, atypical target lesions, mucocutaneous erosions | Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement | Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation |
| Lymph node enlargement | +++ | - | + | + |
| Neutrophils | Elevated | Decreased | Very elevated | Elevated |
| Eosinophils | Very elevated | No change | Elevated | Elevated |
| Atypical lymphocytes | + | - | - | + |
| Hepatitis | +++ | ++ | ++ | - |
| Other organ involvement | Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis | Tubular nephritis and tracheobronical necrosis | Possible | Possible |
| Histological pattern of skin | Perivascular lymphocytcic infiltrate | Epidermal necrosis | Subcorneal pustules | Nonspecific, unless reflecting Sezary syndrome or other lymphoma |
| Lymph node histology | Lymphoid hyperplasia | - | - | No, unless reflecting Sezary syndrome or other malignancy |
| Mortality (%) | 10 | 5-35 | 5 | 5-15 |
- AGEP Acute generalized exanthematous pustulosis
- DRESS drug reaction with eosinophilia and systemic symptoms
- SJS Stevens-Johnson syndrome
- TEN toxic epidermal necrolysis