Osteosarcoma: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Often an adolescent during a growth spurt | |||
*Bone pain for several months that worsens with activity and is more painful at night | |||
*Absence of constitutional symptoms (e.g., fevers, weight loss, night sweats, and decreased appetite are typically absent) | |||
*Large soft tissue mass on exam that is tender to palpation | |||
*Occurs at metaphysis of long bones | |||
**Most commonly at the distal femur followed by the proximal tibia | |||
*Less frequently presents as pathological fracture | |||
*Risk factors include prior cancer treatment, [[Paget disease]] of bone, benign bone disease, Hereditary Retinoblastoma or Li-Fraumeni syndrome | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 21:37, 21 November 2019
Background
- Most common primary pediatric bone tumor
- 3% of all childhood cancers
- Around two-thirds of those diagnosed with non-metastatic disease under the age of 40 will be long-term survivors or cured of the disease with appropriate treatment
- Survival is less than 20 percent with metastatic disease
- Bimodal as it peaks in early adolescence and over the age of 65
Pathophysiology
- Overproduction of osteoid and immature bone by malignant osteoblasts
Clinical Features
- Often an adolescent during a growth spurt
- Bone pain for several months that worsens with activity and is more painful at night
- Absence of constitutional symptoms (e.g., fevers, weight loss, night sweats, and decreased appetite are typically absent)
- Large soft tissue mass on exam that is tender to palpation
- Occurs at metaphysis of long bones
- Most commonly at the distal femur followed by the proximal tibia
- Less frequently presents as pathological fracture
- Risk factors include prior cancer treatment, Paget disease of bone, benign bone disease, Hereditary Retinoblastoma or Li-Fraumeni syndrome