Atovaquone: Difference between revisions

Revision as of 01:53, 20 March 2026

Type: Antimicrobial (active against Pneumocystis jirovecii, Babesiosis, Toxoplasmosis, Malaria)
Dosage Forms: tablet, oral suspion
Dosage Strengths: tablet: 250mg; oral suspension: 750mg/5mL
Routes of Administration: PO
Common Trade Names: Mepron

Disease	Dose	Context
Babesiosis	750mg BID x 10 days	Mild parasitemia less than 4 percent option 1

Pregnancy Rating: C
Lactation risk: Infant risk cannot be ruled out
Renal dosing: atovaquone/proguanil contraindicated in severe renal failure for malaria prophylaxis, otherwise no adjustment
Hepatic dosing: no adjustment

Unclear mechanism; structurally similar to ubiquonone, which inhibits cytochromal electron transport in Plasmodia species

Authors:

@@ Line 7: / Line 7: @@
 ==Adult Dosing==
-*Babesiosis: 750mg PO q12h + azithromycin
+===Indications by Disease===
-*Toxoplasma encephalitis, HIV+: 1500mg daily + leucovorin +/- pyrimethamine
+{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Adult]]
-*PCP pneumonia (2nd line): 1500mg daily
+|?Treats disease=Disease
-*Malaria prophylaxis:
+|?Has Dose=Dose
+|?Has Context=Context
+|format=table
+|limit=50
+|mainlabel=-
+|headers=show
+|sort=Treats disease
+}}
 ==Pediatric Dosing==
-*Babesiosis: 20mg/kg q12h (max 750mg/dose) + azithromycin
+===Indications by Disease===
-*PCP pneumonia (2nd line)
+{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Pediatric]]
-**>13yo,  HIV- : 1500mg daily
+|?Treats disease=Disease
-**Adolescents, HIV+: 1500mg daily +/- leucovorin, +/- pyrimethamine
+|?Has Dose=Dose
-**1-3mo, 2-13yo, HIV+: 30 mg/kg PO daily
+|?Has Context=Context
-**4-24mo, HIV+: 45mg/kg PO daily
+|format=table
-*Malaria prophylaxis: 250mg + 100mg proguanil daily
+|limit=50
-*Malaria falciparum/vivax treatment: 1000mg + proguanil 400mg daily
+|mainlabel=-
+|headers=show
+|sort=Treats disease
+}}
 ==Special Populations==