Ertapenem

General

• Type: Carbapenems
• Dosage Forms: IM, IV
• Common Trade Names: Invanz

Adult Dosing

General

• 1g IM/IV daily x 5-14 days
• First Dose: 1g IM/IV x 1

Specific Indications

• 1g IM/IV daily for all
• Intrabdominal infections x 5-14 days
• Skin infections = x 7-14 days
• Pneumonia, community aquired x 10-14 days
• UTI, complicated = x 10-14 days
• Gynecologic = x 3-10 days
• Prophylaxis, colorectal surg = x 1 dose

Pediatric Dosing

General (3mo-12 years)

• 30 mg/kg/day IM/IV divided BID x 5-14 days
• First Dose: 15 mg/kg IM/IV x 1
• Max: 1 g/day
• For duration, see adult specific indication dosing

General (>13 Years)

See adult dosing

Special Populations

• Pregnancy: B
• Lactation: Safety unknown
• Renal Dosing
  • Adult
    • CrCl <30: 500mg daily
    • Hemodyalisis: give 150mg supplement if maintenance dose <6h prior
  • Pediatric
    • CrCl <30: decrease dose 50%
    • Hemodyalisis: give 150mg supplement if maintenance dose <6h prior
• Hepatic Dosing (Adult & Pediatric)
  • No data

Contraindications

• Allergy to class/drug
• Hypersensitivity to amide anesthetics (IM only)

Cautions

• Hypersensitivity to Beta-Lactam
• Seizure history
• CNS disorder
• Renal impairment
• Recent antibiotic associated colitis

Adverse Reactions

Serious

• Hypersensitivity Reaction
• Anaphylaxis
• Neurotoxicity
• Seizures
• C. diff
• Superinfection
• Extravasation with tissue damage
• Hallucinations
• Hypertension
• Tachycardia
• Drug rash with eosinophilia

Common

• Diarrhea
• Infusion site reaction
• Nausea and Vomiting
• Transaminitis
• Headache
• Fever
• Altered Mental Status
• Constipation
• Abdominal Pain
• Edema
• Insomnia
• Thrombocytosis
• Dyspnea
• Rash
• Dizziness
• Puritis
• Hypotension
• Vaginitis

Pharmacology

• Half-life: 4h
• Metabolism: CYP450
• Excretion: Urine (80%)
• Mechanism of Action: Bactericidal

See Also

• Antibiotics

Source

• Epocrates