Salvia toxicity: Difference between revisions
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==Background== | |||
*Historically used by shamans in rituals | *Historically used by shamans in rituals | ||
*Active ingredient: Salvinorin A | *Active ingredient: Salvinorin A | ||
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*Does not appear on typical tox screens | *Does not appear on typical tox screens | ||
==Clinical Features== | |||
*Uncontrollable laughter | *Uncontrollable laughter | ||
*Intense hallucinations | *Intense hallucinations | ||
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*Few reports of psychosis and suicide associated with use | *Few reports of psychosis and suicide associated with use | ||
==Treatment== | |||
*Supportive | *Supportive | ||
*Benzodiazepines as needed | *Benzodiazepines as needed | ||
*Most patients will have symptoms resolve prior to ED arrival given short duration of action | *Most patients will have symptoms resolve prior to ED arrival given short duration of action | ||
==Source== | |||
David Burbulys, MD lecture 9/2012 | David Burbulys, MD lecture 9/2012 | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 15:07, 25 September 2012
Background
- Historically used by shamans in rituals
- Active ingredient: Salvinorin A
- Kappa opiod receptor agonist and D2 agonist
- Hallucinogen
- Dissociative effects similar to ketamine
- Tea: 10 min onset, duration 30-90 min
- Smoked: 1-2 minute onset, tapers over 10-20 min
- Does not appear on typical tox screens
Clinical Features
- Uncontrollable laughter
- Intense hallucinations
- Diaphoresis
- Sensations of motion, lights, visions, overlapping realities
- Low toxicity, little hangover, low abuse potential
- Few reports of psychosis and suicide associated with use
Treatment
- Supportive
- Benzodiazepines as needed
- Most patients will have symptoms resolve prior to ED arrival given short duration of action
Source
David Burbulys, MD lecture 9/2012