Phentolamine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*Pheochromocytomectomy adjunct: 5mg IM/IV q2-4h | *Pheochromocytomectomy adjunct: 5mg IM/IV q2-4h PRN | ||
**Start: 1-2h preop | **Start: 1-2h preop | ||
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**Start: within 12h of extravasation | **Start: within 12h of extravasation | ||
*[[Hypertensive crisis]]: 5mg IM/IV q2-4h | *[[Hypertensive crisis]]: 5mg IM/IV q2-4h PRN | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Pheochromocytomectomy adjunct: 1mg IM/IV q2-4h | *Pheochromocytomectomy adjunct: 1mg IM/IV q2-4h PRN | ||
**Start: 1-2h preop | **Start: 1-2h preop | ||
Revision as of 12:41, 7 July 2017
Administration
- Type: Alpha 1 Blocker; Antidote, Extravasation; Antihypertensive
- Routes of Administration: IV, IM
- Common Trade Names: OraVerse
Adult Dosing
- Pheochromocytomectomy adjunct: 5mg IM/IV q2-4h PRN
- Start: 1-2h preop
- Extravasation (norepinephrine-associated): 5-10mg injected into affected area x1
- Start: within 12h of extravasation
- Hypertensive crisis: 5mg IM/IV q2-4h PRN
Pediatric Dosing
- Pheochromocytomectomy adjunct: 1mg IM/IV q2-4h PRN
- Start: 1-2h preop
Special Populations
- Pregnancy Risk Factor: C
Renal Dosing
- No dosing adjustments
Hepatic Dosing
- No dosing adjustments
Contraindications
Adverse Reactions
Serious
- MI
- stroke
- hypotension, severe
- arrhythmias
- PUD
- priapism
Common
- tachycardia
- weakness
- dizziness
- flushing
- orthostatic hypotension
- nasal congestion
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 19 minutes
- Metabolism: Urine
- Excretion: CYP450
Mechanism of Action
References
<Epocrates, UpToDate>