Santa Monica:Antibiotics in Sepsis: Difference between revisions
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==Unknown Source== | ==Unknown Source== | ||
*Primary Therapy | *Primary Therapy | ||
**[[piperacillin/tazobactam]]4.5g IV q6h OR cefepime 1g IV q8h OR meropenem 1g IV q8h | **[[piperacillin/tazobactam]]4.5g IV q6h '''OR''' cefepime 1g IV q8h '''OR''' meropenem 1g IV q8h | ||
**+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | **+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | ||
**+/- gentamicin 7mg/kg/dose IV q24h | **+/- [[gentamicin]] 7mg/kg/dose IV q24h | ||
**+/- fluconazole 400mg IV q24h | **+/- fluconazole 400mg IV q24h | ||
*If allergy or prior exposure | *If allergy or prior exposure | ||
**[[aztreonam]] 2g IV q8h OR levofloxacin 750mg IV q24h | **[[aztreonam]] 2g IV q8h '''OR''' levofloxacin 750mg IV q24h | ||
**+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | **+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | ||
**+/- gentamicin 7mg/kg/dose IV q24h | **+/- [[gentamicin]] 7mg/kg/dose IV q24h | ||
**+/- fluconazole 400mg IV q24h | **+/- fluconazole 400mg IV q24h | ||
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==Pneumonia (Healthcare Assoc/Pseudomonas Risk)== | ==Pneumonia (Healthcare Assoc/Pseudomonas Risk)== | ||
*Primary therapy | *Primary therapy | ||
**cefepime 1g IV q8h OR [[piperacillin/tazobactam]]4.5g IV q6h | **cefepime 1g IV q8h '''OR''' [[piperacillin/tazobactam]]4.5g IV q6h | ||
**+/- azithromycin 500mg IV q24h | **+/- azithromycin 500mg IV q24h | ||
**+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | **+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | ||
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**levofloxacin 750mg IV q24h | **levofloxacin 750mg IV q24h | ||
**+/- azithromycin 500mg IV q24h | **+/- azithromycin 500mg IV q24h | ||
**+/- gentamicin extended interval 7mg/kg/dose IV q24h | **+/- [[gentamicin]] extended interval 7mg/kg/dose IV q24h | ||
==Abdominal/Pelvic== | ==Abdominal/Pelvic== | ||
*Primary therapy | *Primary therapy | ||
**[[piperacillin/tazobactam]]4.5g IV q6h OR [[ertapenem]] 1g IV q24h OR ceftriaxone 1g IV q24h | **[[piperacillin/tazobactam]]4.5g IV q6h '''OR''' [[ertapenem]] 1g IV q24h '''OR''' [[ceftriaxone]] 1g IV q24h | ||
**AND, metronidazole 500mg IV q8h | **AND, [[metronidazole]] 500mg IV q8h | ||
**[[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | **[[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | ||
*If allergy or prior exposure | *If allergy or prior exposure | ||
**[[aztreonam]] 2g IV q8h | **[[aztreonam]] 2g IV q8h | ||
**AND, metronidazole 500mg IV q8h | **AND, [[metronidazole]] 500mg IV q8h | ||
**+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | **+/- [[vancomycin]] 15mg/kg/dose IV q12h [Maximum dose of 1500mg] | ||
==Urosepsis== | ==Urosepsis== | ||
*Primary therapy | *Primary therapy | ||
**ertapenem 1g IV q24h OR ceftriaxone 1g IV q24h | **ertapenem 1g IV q24h '''OR''' [[ceftriaxone]] 1g IV q24h | ||
*If allergy or prior exposure | *If allergy or prior exposure | ||
**[[ciprofloxacin]] 400mg IV q12h OR [[ciprofloxacin]] 400mg IV q12h | **[[ciprofloxacin]] 400mg IV q12h '''OR''' [[ciprofloxacin]] 400mg IV q12h | ||
**AND, gentamicin 7mg/kg/dose IV q24h | **AND, [[gentamicin]] 7mg/kg/dose IV q24h | ||
==Heme/Onch== | ==Heme/Onch== | ||
Latest revision as of 01:28, 31 May 2017
Unknown Source
- Primary Therapy
- piperacillin/tazobactam4.5g IV q6h OR cefepime 1g IV q8h OR meropenem 1g IV q8h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
- +/- gentamicin 7mg/kg/dose IV q24h
- +/- fluconazole 400mg IV q24h
- If allergy or prior exposure
- aztreonam 2g IV q8h OR levofloxacin 750mg IV q24h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
- +/- gentamicin 7mg/kg/dose IV q24h
- +/- fluconazole 400mg IV q24h
Pneumonia (Community)
- Comm. Acquired
- Ceftriaxone 1g IV q24h
- AND, Azithromycin 500mg IV q24h
- If allergy or prior exposure
- Levofloxacin 750mg IV q24h AND Aztreonam 2g IV q8h
Pneumonia (Healthcare Assoc/Pseudomonas Risk)
- Primary therapy
- cefepime 1g IV q8h OR piperacillin/tazobactam4.5g IV q6h
- +/- azithromycin 500mg IV q24h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
- If allergy or prior exposure
- levofloxacin 750mg IV q24h
- +/- azithromycin 500mg IV q24h
- +/- gentamicin extended interval 7mg/kg/dose IV q24h
Abdominal/Pelvic
- Primary therapy
- piperacillin/tazobactam4.5g IV q6h OR ertapenem 1g IV q24h OR ceftriaxone 1g IV q24h
- AND, metronidazole 500mg IV q8h
- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
- If allergy or prior exposure
- aztreonam 2g IV q8h
- AND, metronidazole 500mg IV q8h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
Urosepsis
- Primary therapy
- ertapenem 1g IV q24h OR ceftriaxone 1g IV q24h
- If allergy or prior exposure
- ciprofloxacin 400mg IV q12h OR ciprofloxacin 400mg IV q12h
- AND, gentamicin 7mg/kg/dose IV q24h
Heme/Onch
- Primary therapy
- meropenem 1g IV q8h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
- If allergy or prior exposure
- aztreonam 2g IV q8h
- +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
See Also
References
Santa-Monica UCLA 5/12