Methadone: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: opioid | *Type: [[opioid]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral, IM/subcutaneous | *Routes of Administration: oral, IM/subcutaneous | ||
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Varies widely due to patient variability in ADME, tolerance, indication | |||
* | *Usual doses: | ||
**Opioid use disorder, maintenance: 40-120mg/day or higher | |||
**Pain: initial dose 2.5mg TID for opioid naive | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established in pediatric patients'' | |||
*0.1-0.2mg/kg q6h | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Category C | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: infant risk minimal | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: lower initial starting dose | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: lower initial starting dose | ||
==Contraindications== | ==Contraindications== | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[QTc prolongation]] | |||
*[[Torsades de pointes]] | |||
*Respiratory depression/acidosis/arrest | |||
===Common=== | ===Common=== | ||
*[[Constipation]] | |||
*[[Nausea/vomiting]] | |||
*Sedation | |||
*[[Dizziness]] | |||
*[[Hypotension]] | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 8-59 hours | ||
*Metabolism: | *Metabolism: mostly hepatic | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Synthetic opioid | |||
==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Methadone]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
Latest revision as of 21:57, 20 March 2026
Administration
- Type: opioid
- Dosage Forms:
- Routes of Administration: oral, IM/subcutaneous
- Common Trade Names:
Adult Dosing
- Varies widely due to patient variability in ADME, tolerance, indication
- Usual doses:
- Opioid use disorder, maintenance: 40-120mg/day or higher
- Pain: initial dose 2.5mg TID for opioid naive
Pediatric Dosing
Safety/efficacy not established in pediatric patients
- 0.1-0.2mg/kg q6h
Special Populations
- Pregnancy Rating: Category C
- Lactation risk: infant risk minimal
Renal Dosing
- Adult: lower initial starting dose
Hepatic Dosing
- Adult: lower initial starting dose
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- QTc prolongation
- Torsades de pointes
- Respiratory depression/acidosis/arrest
Common
- Constipation
- Nausea/vomiting
- Sedation
- Dizziness
- Hypotension
Pharmacology
- Half-life: 8-59 hours
- Metabolism: mostly hepatic
Mechanism of Action
- Synthetic opioid
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Opioid withdrawal | 10mg IM or 30mg PO | Opioid replacement for withdrawal from interrupted opioid use (not antagonist-precipitated) | IM/PO | Adult |
| Opioid withdrawal (peds) | 10mg IM or 30mg PO | Withdrawal from interrupted opioid use | IM/PO | Adult |