Pyridoxine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Hyperemesis gravidarum]]=== | |||
*10-25mg q6-8hrs | |||
===[[Seizures]] associated with overdose of [[INH]] or ingestion of [[gyromitra]] mushrooms <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref> <ref>Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.</ref>=== | |||
*Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams | |||
*Unknown quantity ingested: 5 grams | |||
*IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Seizures associated with overdose of [[INH]]=== | |||
*Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams | |||
*Unknown quantity ingested: 70mg/kg up to 5 gm (adult dose) <ref>Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381 </ref> | |||
*Then give 1 gram IM q30min until total dose required reached<ref>Pyridoxine. www.Drugs.com. http://www.drugs.com/dosage/pyridoxine.html</ref> | |||
===[[Gyromitra]] ingestion=== | |||
*70mg/kg initial dose | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: A | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: May inhibit lactation when given in high amounts | ||
==Contraindications== | ==Contraindications== | ||
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===Common=== | ===Common=== | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Pyridoxine]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
[[Antidotes]] | *[[Antidotes]] | ||
*[[INH]] | |||
*[[Vitamin deficiencies]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:FEN]] | |||
Latest revision as of 21:57, 20 March 2026
Administration
- Type: Water soluble vitamin
- Routes of Administration: Oral, IV/IM
- Common Trade Names: Vitamin B6
Adult Dosing
Hyperemesis gravidarum
- 10-25mg q6-8hrs
Seizures associated with overdose of INH or ingestion of gyromitra mushrooms [1] [2]
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 5 grams
- IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours
Pediatric Dosing
Seizures associated with overdose of INH
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 70mg/kg up to 5 gm (adult dose) [3]
- Then give 1 gram IM q30min until total dose required reached[4]
Gyromitra ingestion
- 70mg/kg initial dose
Special Populations
- Pregnancy Rating: A
- Lactation risk: May inhibit lactation when given in high amounts
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Mechanism of Action
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Ethylene glycol toxicity | 50 mg q6hr x2 days | Decrease oxalate production | IV | Adult |
| Hyperemesis gravidarum | 10-25 mg q6-8hr | 1st line antiemetic (Vitamin B6) | PO | Adult |
| Isoniazid toxicity | Gram-for-gram of INH ingested (empiric: 5 g) | Specific antidote | IV at 1 g/min | Adult |
| Isoniazid toxicity | 70 mg/kg | Specific antidote | IV at 1 g/min | Pediatric |
| Seizure (peds) | 100mg | Pyridoxine-responsive seizure disorder | IV | Pediatric |
See Also
References
- ↑ Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175.
- ↑ Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.
- ↑ Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381
- ↑ Pyridoxine. www.Drugs.com. http://www.drugs.com/dosage/pyridoxine.html