Isoproterenol: Difference between revisions
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== | ==General== | ||
*Type: Beta agonist; [[Antiarrhythmics]] | |||
*Dosage Forms: IV or IM injection | |||
*Common Trade Names: Isoprenaline, Isuprel | |||
== | ==Adult Dosing== | ||
* | *Loading dose: 0.02-0.06 mg IV, followed by infusion<ref>GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.</ref><ref>AthenaHealth. Epocrates. Isoproterenol - Entire Monograph. https://online.epocrates.com/u/10a106/isoproterenol.</ref> | ||
* | **2-20 mcg/min IV infusion | ||
**Titrate to HR and BP | |||
*Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN | |||
== | ==Pediatric Dosing== | ||
* | *No well controlled studies for appropriate dosing | ||
*AHA recommends initial infusion of 0.1 mcg/kg/min, with titrated range usually 0.1-1 mcg/kg/min<ref>GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.</ref> | |||
== Adverse | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | |||
*[[Lactation risk categories|Lactation risk]]: Unknown | |||
*Renal Dosing - undefined | |||
*Hepatic Dosing - undefined | |||
==Indications== | |||
*Refractory [[torsades]] | |||
*Refractory symptomatic [[bradycardia]] | |||
*Refractory [[electrical storm]] | |||
*[[Brugada syndrome]] | |||
==Contraindications== | |||
*Allergy to class/drug | |||
==Adverse Reactions== | |||
*Dramatic increase in O2 demand | *Dramatic increase in O2 demand | ||
*V-tach (use lowest dose possible) | *V-tach (use lowest dose possible) | ||
== Kinetics == | ==Pharmacology== | ||
*Onset of action = 1- | *Half-life: 2-10 min<ref>Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.</ref> | ||
*Duration of action = 1- | *Metabolism: liver, CYP450 | ||
*Excretion: urine primarily | |||
*Mechanism of Action: Beta adrenergic agonist | |||
===Kinetics=== | |||
*Onset of action = 1-5 min | |||
*Duration of action = 1-2 hr | |||
==Comments== | |||
==See Also== | ==See Also== | ||
[[Antiarrhythmics]] | *[[Antiarrhythmics]] | ||
[[Category: | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category:Cardiology]] | |||
Latest revision as of 19:17, 29 December 2023
General
- Type: Beta agonist; Antiarrhythmics
- Dosage Forms: IV or IM injection
- Common Trade Names: Isoprenaline, Isuprel
Adult Dosing
- Loading dose: 0.02-0.06 mg IV, followed by infusion[1][2]
- 2-20 mcg/min IV infusion
- Titrate to HR and BP
- Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN
Pediatric Dosing
- No well controlled studies for appropriate dosing
- AHA recommends initial infusion of 0.1 mcg/kg/min, with titrated range usually 0.1-1 mcg/kg/min[3]
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown
- Renal Dosing - undefined
- Hepatic Dosing - undefined
Indications
- Refractory torsades
- Refractory symptomatic bradycardia
- Refractory electrical storm
- Brugada syndrome
Contraindications
- Allergy to class/drug
Adverse Reactions
- Dramatic increase in O2 demand
- V-tach (use lowest dose possible)
Pharmacology
- Half-life: 2-10 min[4]
- Metabolism: liver, CYP450
- Excretion: urine primarily
- Mechanism of Action: Beta adrenergic agonist
Kinetics
- Onset of action = 1-5 min
- Duration of action = 1-2 hr
Comments
See Also
References
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ AthenaHealth. Epocrates. Isoproterenol - Entire Monograph. https://online.epocrates.com/u/10a106/isoproterenol.
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.