Esmolol: Difference between revisions
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== Adult Dosing == | ==General== | ||
*Type: [[Beta blockers]] | |||
*Dosage Forms: | |||
*Common Trade Names: Brevibloc | |||
==Adult Dosing== | |||
*Loading dose = 500mcg/kg bolus over 1min | *Loading dose = 500mcg/kg bolus over 1min | ||
**Follow this | **Follow this with infusion at 50mcg/kg/min for 4min | ||
***If no response give another 500 bolus, | ***If no response give another 500 bolus, increased infusion to 100 | ||
***If no response give another 500 bolus, | ***If no response give another 500 bolus, increased infusion to 200 | ||
*Symptomatic AAA (controversial) | |||
**500mcg/kg bolus | |||
**Infusion of 50-200mcg/kg/min titrated to goal SBP | |||
==Pediatric Dosing== | |||
==Special Populations== | |||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | |||
*Lactation: Unknown if excreted in breast milk | |||
*Renal Dosing | |||
**Adult: No adjustment required | |||
*Hepatic Dosing | |||
**Adult: No adjustment required | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | |||
*Cardiogenic shock | *Cardiogenic shock | ||
*2nd or 3rd AV block | *2nd or 3rd AV block | ||
== Indications == | ==Indications== | ||
*Supraventricular arrhythmias | *Supraventricular arrhythmias | ||
*Heart rate and blood pressure control in Symptomatic Aortic Aneurysm (titrate to HR <60 bmp) | |||
*Off label use: refractory [[VF]] | |||
==Adverse Reactions== | |||
== Adverse | |||
*Hypotension | *Hypotension | ||
*Bronchospasm | *Bronchospasm | ||
== | ==Pharmacology== | ||
Onset of action = 1-4min Duration of action = <30min | *Half-life: Adults - 9min Children 18mo-16yrs 2.7-4.8min | ||
*Metabolism: Red Blood Cell Esterase | |||
*Excretion: Renal | |||
*Mechanism of Action: Class II - Short-acting Beta1 blocker | |||
*Onset of action = 1-4min | |||
*Duration of action = <30min | |||
==See Also== | ==See Also== | ||
[[Antiarrhythmics]] | *[[Beta-blockers]] | ||
*[[Beta-blocker toxicity]] | |||
*[[Antiarrhythmics]] | |||
*[[Antihypertensive medications]] | |||
==References== | |||
<references/> | |||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
[[Category:Critical Care]] | |||
Latest revision as of 01:25, 7 March 2021
General
- Type: Beta blockers
- Dosage Forms:
- Common Trade Names: Brevibloc
Adult Dosing
- Loading dose = 500mcg/kg bolus over 1min
- Follow this with infusion at 50mcg/kg/min for 4min
- If no response give another 500 bolus, increased infusion to 100
- If no response give another 500 bolus, increased infusion to 200
- Follow this with infusion at 50mcg/kg/min for 4min
- Symptomatic AAA (controversial)
- 500mcg/kg bolus
- Infusion of 50-200mcg/kg/min titrated to goal SBP
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown if excreted in breast milk
- Renal Dosing
- Adult: No adjustment required
- Hepatic Dosing
- Adult: No adjustment required
Contraindications
- Allergy to class/drug
- Cardiogenic shock
- 2nd or 3rd AV block
Indications
- Supraventricular arrhythmias
- Heart rate and blood pressure control in Symptomatic Aortic Aneurysm (titrate to HR <60 bmp)
- Off label use: refractory VF
Adverse Reactions
- Hypotension
- Bronchospasm
Pharmacology
- Half-life: Adults - 9min Children 18mo-16yrs 2.7-4.8min
- Metabolism: Red Blood Cell Esterase
- Excretion: Renal
- Mechanism of Action: Class II - Short-acting Beta1 blocker
- Onset of action = 1-4min
- Duration of action = <30min